Description: Homo sapiens golgi reassembly stacking protein 2, 55kDa (GORASP2), transcript variant 2, mRNA. RefSeq Summary (NM_001201428): This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr2:171,784,948-171,823,643 Size: 38,696 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr2:171,806,109-171,822,640 Size: 16,532 Coding Exon Count: 8
ID:GORS2_HUMAN DESCRIPTION: RecName: Full=Golgi reassembly-stacking protein 2; Short=GRS2; AltName: Full=Golgi phosphoprotein 6; Short=GOLPH6; AltName: Full=Golgi reassembly-stacking protein of 55 kDa; Short=GRASP55; AltName: Full=p59; FUNCTION: Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. SUBUNIT: Forms a RAB2 effector complex with BLZF1/Golgin 45 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Does not interact with GM130. Interacts with KCTD5. Interacts with TMED2 and TMED3 (By similarity). INTERACTION: P13569:CFTR; NbExp=3; IntAct=EBI-739467, EBI-349854; SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor. Membrane; Peripheral membrane protein. PTM: Myristoylated. Myristoylation is essential for the Golgi targeting (By similarity). PTM: Palmitoylated. PTM: Phosphorylated in mitotic cells. SIMILARITY: Belongs to the GORASP family. SIMILARITY: Contains 1 PDZ (DHR) domain.
Cognitive performance Need ,et al. 2009, A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery, Human molecular genetics 2009 18- 23 : 4650-61.
[PubMed 19734545]
Psychomotor Performance Anna C Need et al. Human molecular genetics 2009, A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB., Human molecular genetics.
[PubMed 19734545]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H8Y8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
