Human Gene DAZAP2 (uc010snd.2) Description and Page Index
  Description: Homo sapiens DAZ associated protein 2 (DAZAP2), transcript variant 3, mRNA.
RefSeq Summary (NM_001136266): This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr12:51,632,508-51,637,717 Size: 5,210 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr12:51,632,692-51,636,436 Size: 3,745 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:51,632,508-51,637,717)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIOMIM
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8VU62_HUMAN
DESCRIPTION: SubName: Full=DAZ-associated protein 2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: DAZAP2
Diseases sorted by gene-association score: multiple myeloma (8), azoospermia (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 143.51 RPKM in Whole Blood
Total median expression: 3629.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.51184-0.416 Picture PostScript Text
3' UTR -332.661281-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022730 - DAZ_assoc-2

Pfam Domains:
PF11029 - DAZ associated protein 2 (DAZAP2)

ModBase Predicted Comparative 3D Structure on F8VU62
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF210452 - JP 2014500723-A/17955: Polycomb-Associated Non-Coding RNAs.
AK303828 - Homo sapiens cDNA FLJ57772 complete cds, highly similar to DAZ-associated protein 2.
AK290119 - Homo sapiens cDNA FLJ76603 complete cds, highly similar to Homo sapiens DAZ associated protein 2 (DAZAP2), mRNA.
AY430097 - Homo sapiens DAZAP2 (DAZAP2) mRNA, complete cds.
BX647278 - Homo sapiens mRNA; cDNA DKFZp686F0899 (from clone DKFZp686F0899).
AK293330 - Homo sapiens cDNA FLJ59575 complete cds, highly similar to DAZ-associated protein 2.
D31767 - Homo sapiens KIAA0058 mRNA.
BC002334 - Homo sapiens DAZ associated protein 2, mRNA (cDNA clone MGC:766 IMAGE:3509229), complete cds.
BC007900 - Homo sapiens DAZ associated protein 2, mRNA (cDNA clone MGC:14319 IMAGE:4297784), complete cds.
AK095963 - Homo sapiens cDNA FLJ38644 fis, clone HHDPC2005742, moderately similar to Mus musculus proline-rich protein (Bprp) mRNA.
LF337998 - JP 2014500723-A/145501: Polycomb-Associated Non-Coding RNAs.
AB385271 - Synthetic construct DNA, clone: pF1KA0058, Homo sapiens DAZAP2 gene for DAZ-associated protein 2, complete cds, without stop codon, in Flexi system.
CU677910 - Synthetic construct Homo sapiens gateway clone IMAGE:100017954 5' read DAZAP2 mRNA.
HQ447212 - Synthetic construct Homo sapiens clone IMAGE:100070512; CCSB003598_02 DAZ associated protein 2 (DAZAP2) gene, encodes complete protein.
KJ892852 - Synthetic construct Homo sapiens clone ccsbBroadEn_02246 DAZAP2 gene, encodes complete protein.
AK125855 - Homo sapiens cDNA FLJ43867 fis, clone TESTI4008018, moderately similar to Homo sapiens DAZ associated protein 2 (DAZAP2).
JD443661 - Sequence 424685 from Patent EP1572962.
JD528790 - Sequence 509814 from Patent EP1572962.
JD434698 - Sequence 415722 from Patent EP1572962.
JD374825 - Sequence 355849 from Patent EP1572962.
JD184543 - Sequence 165567 from Patent EP1572962.
JD306485 - Sequence 287509 from Patent EP1572962.
JD494420 - Sequence 475444 from Patent EP1572962.
JD494421 - Sequence 475445 from Patent EP1572962.
LF338001 - JP 2014500723-A/145504: Polycomb-Associated Non-Coding RNAs.
JD512269 - Sequence 493293 from Patent EP1572962.
JD248142 - Sequence 229166 from Patent EP1572962.
JD555578 - Sequence 536602 from Patent EP1572962.
JD086471 - Sequence 67495 from Patent EP1572962.
JD456252 - Sequence 437276 from Patent EP1572962.
JD078016 - Sequence 59040 from Patent EP1572962.
LF338003 - JP 2014500723-A/145506: Polycomb-Associated Non-Coding RNAs.
JD530996 - Sequence 512020 from Patent EP1572962.
LF338004 - JP 2014500723-A/145507: Polycomb-Associated Non-Coding RNAs.
JD564243 - Sequence 545267 from Patent EP1572962.
LF338005 - JP 2014500723-A/145508: Polycomb-Associated Non-Coding RNAs.
MA446029 - JP 2018138019-A/17955: Polycomb-Associated Non-Coding RNAs.
MA573575 - JP 2018138019-A/145501: Polycomb-Associated Non-Coding RNAs.
MA573578 - JP 2018138019-A/145504: Polycomb-Associated Non-Coding RNAs.
MA573580 - JP 2018138019-A/145506: Polycomb-Associated Non-Coding RNAs.
MA573581 - JP 2018138019-A/145507: Polycomb-Associated Non-Coding RNAs.
MA573582 - JP 2018138019-A/145508: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: F8VU62, F8VU62_HUMAN, NM_001136266, NP_001129738
UCSC ID: uc010snd.2
RefSeq Accession: NM_001136266
Protein: F8VU62 CCDS: CCDS44885.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001136266.1
exon count: 4CDS single in 3' UTR: no RNA size: 2105
ORF size: 624CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1442.00frame shift in genome: no % Coverage: 99.24
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.