Human Gene DAZAP2 (uc010snd.2) Description and Page Index
Description: Homo sapiens DAZ associated protein 2 (DAZAP2), transcript variant 3, mRNA. RefSeq Summary (NM_001136266): This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. Transcript (Including UTRs) Position: hg19 chr12:51,632,508-51,637,717 Size: 5,210 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr12:51,632,692-51,636,436 Size: 3,745 Coding Exon Count: 4
ID:F8VU62_HUMAN DESCRIPTION: SubName: Full=DAZ-associated protein 2; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11029 - DAZ associated protein 2 (DAZAP2)
ModBase Predicted Comparative 3D Structure on F8VU62
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.