Human Gene TMEM259 (uc002lqr.1) Description and Page Index
  Description: Homo sapiens transmembrane protein 259 (TMEM259), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:1,009,650-1,021,141 Size: 11,492 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr19:1,010,349-1,020,995 Size: 10,647 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:1,009,650-1,021,141)mRNA (may differ from genome)Protein (620 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Membralin;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Note=Cytoplasmic according to PubMed:16084606.
SEQUENCE CAUTION: Sequence=AAC12681.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 133.16 RPKM in Spleen
Total median expression: 3351.20 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.70146-0.505 Picture PostScript Text
3' UTR -354.60699-0.507 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019144 - Membralin

Pfam Domains:
PF09746 - Tumour-associated protein

ModBase Predicted Comparative 3D Structure on Q4ZIN3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0034976 response to endoplasmic reticulum stress
GO:1901215 negative regulation of neuron death
GO:1904294 positive regulation of ERAD pathway

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK090400 - Homo sapiens mRNA for FLJ00277 protein.
BC008957 - Homo sapiens chromosome 19 open reading frame 6, mRNA (cDNA clone MGC:4022 IMAGE:2964663), complete cds.
DQ005958 - Homo sapiens membralin protein mRNA, complete cds.
AK095756 - Homo sapiens cDNA FLJ38437 fis, clone FEBRA2016572, highly similar to Membralin.
AY140906 - Homo sapiens aspecific BCL2 ARE-binding protein 1 (ASBABP1) mRNA, partial cds; alternatively spliced.
JD108205 - Sequence 89229 from Patent EP1572962.
JD395198 - Sequence 376222 from Patent EP1572962.
JD394989 - Sequence 376013 from Patent EP1572962.
JD540767 - Sequence 521791 from Patent EP1572962.
JD045028 - Sequence 26052 from Patent EP1572962.
JD141770 - Sequence 122794 from Patent EP1572962.
JD535943 - Sequence 516967 from Patent EP1572962.
JD178754 - Sequence 159778 from Patent EP1572962.
JD529569 - Sequence 510593 from Patent EP1572962.
JD487120 - Sequence 468144 from Patent EP1572962.
JD235927 - Sequence 216951 from Patent EP1572962.
JD076442 - Sequence 57466 from Patent EP1572962.
JD334430 - Sequence 315454 from Patent EP1572962.
JD173195 - Sequence 154219 from Patent EP1572962.
JD416998 - Sequence 398022 from Patent EP1572962.
JD495608 - Sequence 476632 from Patent EP1572962.
JD372681 - Sequence 353705 from Patent EP1572962.
JD421191 - Sequence 402215 from Patent EP1572962.
JD226882 - Sequence 207906 from Patent EP1572962.
JD520301 - Sequence 501325 from Patent EP1572962.
JD455981 - Sequence 437005 from Patent EP1572962.
DQ893224 - Synthetic construct clone IMAGE:100005854; FLH195394.01X; RZPDo839B11152D chromosome 19 open reading frame 6 (C19orf6) gene, encodes complete protein.
DQ896554 - Synthetic construct Homo sapiens clone IMAGE:100011014; FLH195390.01L; RZPDo839B11151D chromosome 19 open reading frame 6 (C19orf6) gene, encodes complete protein.
KJ899919 - Synthetic construct Homo sapiens clone ccsbBroadEn_09313 C19orf6 gene, encodes complete protein.
CU679197 - Synthetic construct Homo sapiens gateway clone IMAGE:100023454 5' read C19orf6 mRNA.
JD021459 - Sequence 2483 from Patent EP1572962.
JD029870 - Sequence 10894 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf6, MBRL_HUMAN, NM_001033026, NP_001028198, O60392, Q4ZIN3, Q8NF79, Q96H30
UCSC ID: uc002lqr.1
RefSeq Accession: NM_001033026
Protein: Q4ZIN3 (aka MBRL_HUMAN)
CCDS: CCDS32862.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001033026.1
exon count: 11CDS single in 3' UTR: no RNA size: 2754
ORF size: 1863CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2872.00frame shift in genome: no % Coverage: 98.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.