Description: Homo sapiens synovial sarcoma, X breakpoint 5 (SSX5), transcript variant 1, mRNA. RefSeq Summary (NM_021015): The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chrX:48,045,656-48,056,199 Size: 10,544 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chrX:48,047,067-48,054,794 Size: 7,728 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60225-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC016640 - Homo sapiens synovial sarcoma, X breakpoint 5, mRNA (cDNA clone MGC:9494 IMAGE:3923927), complete cds. JD188073 - Sequence 169097 from Patent EP1572962. JD097136 - Sequence 78160 from Patent EP1572962. JD163522 - Sequence 144546 from Patent EP1572962. JD411576 - Sequence 392600 from Patent EP1572962. JD039261 - Sequence 20285 from Patent EP1572962. JD267802 - Sequence 248826 from Patent EP1572962. JD090320 - Sequence 71344 from Patent EP1572962. JD152494 - Sequence 133518 from Patent EP1572962. JD390678 - Sequence 371702 from Patent EP1572962. AX740219 - Sequence 2 from Patent EP1300463. U90842 - Homo sapiens SSX5 (SSX5) mRNA, complete cds. HQ258017 - Synthetic construct Homo sapiens clone IMAGE:100072326 synovial sarcoma, X breakpoint 5 (SSX5) gene, encodes complete protein. KJ897608 - Synthetic construct Homo sapiens clone ccsbBroadEn_07002 SSX5 gene, encodes complete protein. EU446708 - Synthetic construct Homo sapiens clone IMAGE:100070050; IMAGE:100011917; FLH258268.01L synovial sarcoma, X breakpoint 5 (SSX5) gene, encodes complete protein. AB527939 - Synthetic construct DNA, clone: pF1KB0977, Homo sapiens SSX5 gene for Protein SSX5, without stop codon, in Flexi system. JD126038 - Sequence 107062 from Patent EP1572962. JD126037 - Sequence 107061 from Patent EP1572962. JD289109 - Sequence 270133 from Patent EP1572962.
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