Description: Homo sapiens solute carrier family 18 (vesicular monoamine), member 1 (SLC18A1), transcript variant 2, mRNA. RefSeq Summary (NM_003053): The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr8:20,002,366-20,040,717 Size: 38,352 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr8:20,003,274-20,038,475 Size: 35,202 Coding Exon Count: 15
bipolar disorder Lohoff, F. W. et al. 2006, Variations in the Vesicular Monoamine Transporter 1 Gene (VMAT1/SLC18A1) are Associated with Bipolar I Disorder, Neuropsychopharmacology 2006.
[PubMed 16936705]
suggest that variations in the VMAT1 gene may confer susceptibility to BPD in patients of European descent.
major depressive disorder (broad) Shyn ,et al. 2009, Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies, Molecular psychiatry 2009 .
[PubMed 20038947]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07690 - Major Facilitator Superfamily
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on P54219
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006836 neurotransmitter transport GO:0006837 serotonin transport GO:0006855 drug transmembrane transport GO:0015842 aminergic neurotransmitter loading into synaptic vesicle GO:0015844 monoamine transport GO:0015893 drug transport GO:0055085 transmembrane transport
KJ897575 - Synthetic construct Homo sapiens clone ccsbBroadEn_06969 SLC18A1 gene, encodes complete protein. KJ901746 - Synthetic construct Homo sapiens clone ccsbBroadEn_11140 SLC18A1 gene, encodes complete protein. KR710373 - Synthetic construct Homo sapiens clone CCSBHm_00012038 SLC18A1 (SLC18A1) mRNA, encodes complete protein. KR710374 - Synthetic construct Homo sapiens clone CCSBHm_00012039 SLC18A1 (SLC18A1) mRNA, encodes complete protein. BC006317 - Homo sapiens solute carrier family 18 (vesicular monoamine), member 1, mRNA (cDNA clone MGC:12717 IMAGE:4125784), complete cds. BC009387 - Homo sapiens solute carrier family 18 (vesicular monoamine), member 1, mRNA (cDNA clone MGC:15281 IMAGE:4127678), complete cds. U39905 - Human vesicular monoamine transporter VMAT1 mRNA, complete cds. JD551625 - Sequence 532649 from Patent EP1572962. JD404184 - Sequence 385208 from Patent EP1572962. JD303550 - Sequence 284574 from Patent EP1572962. JD133572 - Sequence 114596 from Patent EP1572962. JD496154 - Sequence 477178 from Patent EP1572962. JD507573 - Sequence 488597 from Patent EP1572962. JD489664 - Sequence 470688 from Patent EP1572962. JD042068 - Sequence 23092 from Patent EP1572962. JD180931 - Sequence 161955 from Patent EP1572962. JD276148 - Sequence 257172 from Patent EP1572962. JD165851 - Sequence 146875 from Patent EP1572962. JD214768 - Sequence 195792 from Patent EP1572962. JD133081 - Sequence 114105 from Patent EP1572962. JD322278 - Sequence 303302 from Patent EP1572962. JD456702 - Sequence 437726 from Patent EP1572962. JD199306 - Sequence 180330 from Patent EP1572962. JD133856 - Sequence 114880 from Patent EP1572962. DQ892730 - Synthetic construct clone IMAGE:100005360; FLH189177.01X; RZPDo839C0574D solute carrier family 18 (vesicular monoamine), member 1 (SLC18A1) gene, encodes complete protein. DQ893445 - Synthetic construct Homo sapiens clone IMAGE:100006075; FLH263529.01X; RZPDo839H0982D solute carrier family 18 (vesicular monoamine), member 1 (SLC18A1) gene, encodes complete protein. AK313720 - Homo sapiens cDNA, FLJ94316, highly similar to Homo sapiens solute carrier family 18 (vesicular monoamine), member 1 (SLC18A1), mRNA. DQ895976 - Synthetic construct Homo sapiens clone IMAGE:100010436; FLH189173.01L; RZPDo839C0564D solute carrier family 18 (vesicular monoamine), member 1 (SLC18A1) gene, encodes complete protein. JD270696 - Sequence 251720 from Patent EP1572962. JD491844 - Sequence 472868 from Patent EP1572962. JD528761 - Sequence 509785 from Patent EP1572962. JD527000 - Sequence 508024 from Patent EP1572962. JD052014 - Sequence 33038 from Patent EP1572962. JD097170 - Sequence 78194 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa05012 - Parkinson's disease
Reactome (by CSHL, EBI, and GO)
Protein P54219 (Reactome details) participates in the following event(s):
R-HSA-444160 VMAT1/2 can mediate the transport of biogenic amines R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425428 Amine compound SLC transporters R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules