Human Gene C1QTNF12 (uc001adl.2)
  Description: Homo sapiens family with sequence similarity 132, member A (C1QTNF12), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:1,177,826-1,182,102 Size: 4,277 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr1:1,177,928-1,182,070 Size: 4,143 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,177,826-1,182,102)mRNA (may differ from genome)Protein (302 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HPRDLynxMGIneXtProtOMIMPubMed
TreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F132A_HUMAN
DESCRIPTION: RecName: Full=Protein FAM132A; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the FAM132 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.81 RPKM in Small Intestine - Terminal Ileum
Total median expression: 53.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.2032-0.287 Picture PostScript Text
3' UTR -42.50102-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008983 - Tumour_necrosis_fac-like

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q5T7M4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity

Biological Process:
GO:0010469 regulation of receptor activity
GO:0010906 regulation of glucose metabolic process
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045721 negative regulation of gluconeogenesis
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0051897 positive regulation of protein kinase B signaling

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC089443 - Homo sapiens family with sequence similarity 132, member A, mRNA (cDNA clone MGC:105127 IMAGE:30554756), complete cds.
JD053780 - Sequence 34804 from Patent EP1572962.
JD126230 - Sequence 107254 from Patent EP1572962.
JD408639 - Sequence 389663 from Patent EP1572962.
JD453445 - Sequence 434469 from Patent EP1572962.
JD394851 - Sequence 375875 from Patent EP1572962.
JD341647 - Sequence 322671 from Patent EP1572962.
JD539827 - Sequence 520851 from Patent EP1572962.
JD221781 - Sequence 202805 from Patent EP1572962.
JD289349 - Sequence 270373 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C1QDC2, F132A_HUMAN, FAM132A, NM_001014980, NP_001014980, Q5EBL5, Q5T7M4
UCSC ID: uc001adl.2
RefSeq Accession: NM_001014980
Protein: Q5T7M4 (aka F132A_HUMAN)
CCDS: CCDS30554.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001014980.2
exon count: 8CDS single in 3' UTR: no RNA size: 1052
ORF size: 909CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1265.00frame shift in genome: no % Coverage: 99.14
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.