Human Gene TMPRSS11B (uc003hdw.4)
Description: Homo sapiens transmembrane protease, serine 11B (TMPRSS11B), mRNA.
Transcript (Including UTRs)
Position: hg19 chr4:69,092,371-69,111,412 Size: 19,042 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr4:69,093,629-69,111,276 Size: 17,648 Coding Exon Count: 10
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TM11B_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protease serine 11B; EC=3.4.21.-; AltName: Full=Airway trypsin-like protease 5;
FUNCTION: Probable serine protease (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).SIMILARITY: Belongs to the peptidase S1 family.SIMILARITY: Contains 1 peptidase S1 domain.SIMILARITY: Contains 1 SEA domain.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TMPRSS11B
CDC HuGE Published Literature: TMPRSS11B
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009003 - Pept_cys/ser_Trypsin-like
IPR017329 - Pept_S1A_HAT/DESC1
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR000082 - SEA
Pfam Domains: PF00089 - Trypsin
PF01390 - SEA domain
SCOP Domains: 50494 - Trypsin-like serine proteases
82671 - SEA domain
ModBase Predicted Comparative 3D Structure on Q86T26
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX537945 - Homo sapiens mRNA; cDNA DKFZp686A2412 (from clone DKFZp686A2412); complete cds.AL833167 - Homo sapiens mRNA; cDNA DKFZp686L1818 (from clone DKFZp686L1818); complete cds.JD046525 - Sequence 27549 from Patent EP1572962.JD317091 - Sequence 298115 from Patent EP1572962.JD084506 - Sequence 65530 from Patent EP1572962.JD085060 - Sequence 66084 from Patent EP1572962.JD280367 - Sequence 261391 from Patent EP1572962.JD092301 - Sequence 73325 from Patent EP1572962.JD183939 - Sequence 164963 from Patent EP1572962.JD445290 - Sequence 426314 from Patent EP1572962.JD534582 - Sequence 515606 from Patent EP1572962.JD229408 - Sequence 210432 from Patent EP1572962.JD083184 - Sequence 64208 from Patent EP1572962.JD291676 - Sequence 272700 from Patent EP1572962.JD235938 - Sequence 216962 from Patent EP1572962.JD443041 - Sequence 424065 from Patent EP1572962.JD558856 - Sequence 539880 from Patent EP1572962.JD431052 - Sequence 412076 from Patent EP1572962.JD201474 - Sequence 182498 from Patent EP1572962.JD559707 - Sequence 540731 from Patent EP1572962.JD462393 - Sequence 443417 from Patent EP1572962.JD065822 - Sequence 46846 from Patent EP1572962.JD314169 - Sequence 295193 from Patent EP1572962.AK290904 - Homo sapiens cDNA FLJ75359 complete cds.BC126195 - Homo sapiens transmembrane protease, serine 11B, mRNA (cDNA clone MGC:161473 IMAGE:8991911), complete cds.HQ258410 - Synthetic construct Homo sapiens clone IMAGE:100072839 transmembrane protease, serine 11B (TMPRSS11B) gene, encodes complete protein.KJ900148 - Synthetic construct Homo sapiens clone ccsbBroadEn_09542 TMPRSS11B gene, encodes complete protein.AB528262 - Synthetic construct DNA, clone: pF1KE0196, Homo sapiens TMPRSS11B gene for transmembrane protease, serine 11B, without stop codon, in Flexi system.AM393733 - Synthetic construct Homo sapiens clone IMAGE:100002469 for hypothetical protein (TMPRSS11B gene).AK310210 - Homo sapiens cDNA, FLJ17252.
Other Names for This Gene
Alternate Gene Symbols: A8K4D9, HATL5, NM_182502, NP_872308, Q86T26, TM11B_HUMANUCSC ID: uc003hdw.4RefSeq Accession: NM_182502
Protein: Q86T26
(aka TM11B_HUMAN)
CCDS: CCDS3521.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_182502.3
exon count:
10 CDS single in 3' UTR:
no
RNA size:
2645
ORF size:
1251 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2694.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.