Human Gene TMPRSS11B (uc003hdw.4)
  Description: Homo sapiens transmembrane protease, serine 11B (TMPRSS11B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:69,092,371-69,111,412 Size: 19,042 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr4:69,093,629-69,111,276 Size: 17,648 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:69,092,371-69,111,412)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM11B_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protease serine 11B; EC=3.4.21.-; AltName: Full=Airway trypsin-like protease 5;
FUNCTION: Probable serine protease (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.
SIMILARITY: Contains 1 SEA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMPRSS11B
CDC HuGE Published Literature: TMPRSS11B

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 260.89 RPKM in Esophagus - Mucosa
Total median expression: 318.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.91136-0.102 Picture PostScript Text
3' UTR -316.851258-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR017329 - Pept_S1A_HAT/DESC1
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR000082 - SEA

Pfam Domains:
PF00089 - Trypsin
PF01390 - SEA domain

SCOP Domains:
50494 - Trypsin-like serine proteases
82671 - SEA domain

ModBase Predicted Comparative 3D Structure on Q86T26
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0008150 biological_process

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BX537945 - Homo sapiens mRNA; cDNA DKFZp686A2412 (from clone DKFZp686A2412); complete cds.
AL833167 - Homo sapiens mRNA; cDNA DKFZp686L1818 (from clone DKFZp686L1818); complete cds.
JD046525 - Sequence 27549 from Patent EP1572962.
JD317091 - Sequence 298115 from Patent EP1572962.
JD084506 - Sequence 65530 from Patent EP1572962.
JD085060 - Sequence 66084 from Patent EP1572962.
JD280367 - Sequence 261391 from Patent EP1572962.
JD092301 - Sequence 73325 from Patent EP1572962.
JD183939 - Sequence 164963 from Patent EP1572962.
JD445290 - Sequence 426314 from Patent EP1572962.
JD534582 - Sequence 515606 from Patent EP1572962.
JD229408 - Sequence 210432 from Patent EP1572962.
JD083184 - Sequence 64208 from Patent EP1572962.
JD291676 - Sequence 272700 from Patent EP1572962.
JD235938 - Sequence 216962 from Patent EP1572962.
JD443041 - Sequence 424065 from Patent EP1572962.
JD558856 - Sequence 539880 from Patent EP1572962.
JD431052 - Sequence 412076 from Patent EP1572962.
JD201474 - Sequence 182498 from Patent EP1572962.
JD559707 - Sequence 540731 from Patent EP1572962.
JD462393 - Sequence 443417 from Patent EP1572962.
JD065822 - Sequence 46846 from Patent EP1572962.
JD314169 - Sequence 295193 from Patent EP1572962.
AK290904 - Homo sapiens cDNA FLJ75359 complete cds.
BC126195 - Homo sapiens transmembrane protease, serine 11B, mRNA (cDNA clone MGC:161473 IMAGE:8991911), complete cds.
HQ258410 - Synthetic construct Homo sapiens clone IMAGE:100072839 transmembrane protease, serine 11B (TMPRSS11B) gene, encodes complete protein.
KJ900148 - Synthetic construct Homo sapiens clone ccsbBroadEn_09542 TMPRSS11B gene, encodes complete protein.
AB528262 - Synthetic construct DNA, clone: pF1KE0196, Homo sapiens TMPRSS11B gene for transmembrane protease, serine 11B, without stop codon, in Flexi system.
AM393733 - Synthetic construct Homo sapiens clone IMAGE:100002469 for hypothetical protein (TMPRSS11B gene).
AK310210 - Homo sapiens cDNA, FLJ17252.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4D9, HATL5, NM_182502, NP_872308, Q86T26, TM11B_HUMAN
UCSC ID: uc003hdw.4
RefSeq Accession: NM_182502
Protein: Q86T26 (aka TM11B_HUMAN)
CCDS: CCDS3521.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182502.3
exon count: 10CDS single in 3' UTR: no RNA size: 2645
ORF size: 1251CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2694.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.