Description: Homo sapiens neutrophil cytosolic factor 1C pseudogene (NCF1C), non-coding RNA. RefSeq Summary (NR_003187): The neutrophil cytosolic factor 1 (NCF1) gene encodes the 47 kDa cytosolic subunit of neutrophil NADPH oxidase, which produces superoxide anion. The NCF1 gene is located in close proximity to two highly similar, multi-exon pseudogenes at chromosome 7q11.23, corresponding to this gene record and GeneID:654816. The two pseudogenes contain a dinucleotide deletion (delta-GT) in exon 2 that results in a frameshift and truncation of the open reading frame, and neither pseudogene is likely to express a protein. Recombination events between the pseudogenes and the functional NCF1 gene can inactivate the NCF1 gene and result in chronic granulomatous disease. [provided by RefSeq, Nov 2009]. Transcript (Including UTRs) Position: hg19 chr7:74,572,384-74,587,816 Size: 15,433 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr7:74,572,600-74,587,677 Size: 15,078 Coding Exon Count: 11
ID:NCF1C_HUMAN DESCRIPTION: RecName: Full=Putative neutrophil cytosol factor 1C; Short=NCF-1C; AltName: Full=Putative SH3 and PX domain-containing protein 1C; FUNCTION: May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Contains 1 PX (phox homology) domain. SIMILARITY: Contains 2 SH3 domains. CAUTION: Could be the product of a pseudogene.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A8MVU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.