Description: Homo sapiens T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 1, mRNA. RefSeq Summary (NM_021966): Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr14:96,176,304-96,180,533 Size: 4,230 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr14:96,178,092-96,180,403 Size: 2,312 Coding Exon Count: 3
ID:TCL1A_HUMAN DESCRIPTION: RecName: Full=T-cell leukemia/lymphoma protein 1A; AltName: Full=Oncogene TCL-1; Short=Oncogene TCL1; AltName: Full=Protein p14 TCL1; FUNCTION: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. SUBUNIT: Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Microsome. Endoplasmic reticulum. Note=Microsomal fraction. TISSUE SPECIFICITY: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. DISEASE: Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci. SIMILARITY: Belongs to the TCL1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TCL1ID66.html";
Aromatase Inhibitors James N Ingle et al. Breast cancer research : BCR 2011, Genome-wide case-control study of musculoskeletal adverse events and functional genomics in women receiving aromatase inhibitors: going beyond associations., Breast cancer research : BCR.
[PubMed 21172079]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56279
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019901 protein kinase binding GO:0042802 identical protein binding GO:0043539 protein serine/threonine kinase activator activity
Biological Process: GO:0007275 multicellular organism development GO:0008284 positive regulation of cell proliferation GO:0010918 positive regulation of mitochondrial membrane potential GO:0032461 positive regulation of protein oligomerization GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0043066 negative regulation of apoptotic process GO:0070207 protein homotrimerization GO:0071356 cellular response to tumor necrosis factor GO:0071902 positive regulation of protein serine/threonine kinase activity
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