Description: Homo sapiens integrin, beta 7 (ITGB7), mRNA. RefSeq Summary (NM_000889): This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr12:53,585,107-53,601,000 Size: 15,894 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr12:53,585,340-53,594,227 Size: 8,888 Coding Exon Count: 14
ID:ITB7_HUMAN DESCRIPTION: RecName: Full=Integrin beta-7; AltName: Full=Gut homing receptor beta subunit; Flags: Precursor; FUNCTION: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in a variety of leukocyte lines. INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1. DOMAIN: Domain I contains three cation-binding sites: the ligand- integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding. SIMILARITY: Belongs to the integrin beta chain family. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26010
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC015916 - Homo sapiens integrin, beta 7, mRNA (cDNA clone MGC:20174 IMAGE:4644086), complete cds. LP895269 - Sequence 133 from Patent EP3253886. S80335 - integrin beta 7 subunit [human, mRNA, 2798 nt]. M62880 - Human integrin beta-7 subunit mRNA, complete cds. M68892 - Human integrin beta-7 subunit mRNA, complete cds. AK298239 - Homo sapiens cDNA FLJ58402 complete cds, highly similar to Integrin beta-7 precursor. JD119480 - Sequence 100504 from Patent EP1572962. JD435669 - Sequence 416693 from Patent EP1572962. JD468294 - Sequence 449318 from Patent EP1572962. JD347098 - Sequence 328122 from Patent EP1572962. JD381065 - Sequence 362089 from Patent EP1572962. JD061491 - Sequence 42515 from Patent EP1572962. JD481668 - Sequence 462692 from Patent EP1572962. AK300960 - Homo sapiens cDNA FLJ56554 complete cds, highly similar to Integrin beta-7 precursor. DQ895448 - Synthetic construct Homo sapiens clone IMAGE:100009908; FLH184489.01L; RZPDo839G07143D integrin, beta 7 (ITGB7) gene, encodes complete protein. EU176336 - Synthetic construct Homo sapiens clone IMAGE:100006445; FLH184496.01X; RZPDo839C08251D integrin, beta 7 (ITGB7) gene, encodes complete protein. AB384724 - Synthetic construct DNA, clone: pF1KB3017, Homo sapiens ITGB7 gene for integrin beta-7 precursor, complete cds, without stop codon, in Flexi system. AK311703 - Homo sapiens cDNA, FLJ18745. AK301523 - Homo sapiens cDNA FLJ60922 complete cds, highly similar to Integrin beta-7 precursor.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04510 - Focal adhesion hsa04512 - ECM-receptor interaction hsa04514 - Cell adhesion molecules (CAMs) hsa04672 - Intestinal immune network for IgA production hsa04810 - Regulation of actin cytoskeleton hsa05410 - Hypertrophic cardiomyopathy (HCM) hsa05412 - Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05414 - Dilated cardiomyopathy
Reactome (by CSHL, EBI, and GO)
Protein P26010 (Reactome details) participates in the following event(s):
R-HSA-199032 MADCAM1-1 binds Integrin alpha4beta7 R-HSA-265422 Interaction of integrin alphaEbeta7 with Cadherin-1 R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083 Integrin cell surface interactions R-HSA-1280218 Adaptive Immune System R-HSA-1474244 Extracellular matrix organization R-HSA-168256 Immune System
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