Description: Homo sapiens GRB2-associated binding protein 3 (GAB3), transcript variant 1, mRNA. RefSeq Summary (NM_001081573): This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. Transcript (Including UTRs) Position: hg19 chrX:153,903,527-153,979,348 Size: 75,822 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chrX:153,906,455-153,979,300 Size: 72,846 Coding Exon Count: 10
ID:E9PB44_HUMAN DESCRIPTION: SubName: Full=GRB2-associated-binding protein 3; SIMILARITY: Contains 1 PH domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E9PB44
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
