Human Gene SULT1A4 (uc002dtb.3)
  Description: Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (SULT1A4), mRNA.
RefSeq Summary (NM_177552): Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: hg19 chr16:29,471,207-29,476,301 Size: 5,095 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr16:29,472,707-29,475,896 Size: 3,190 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:29,471,207-29,476,301)mRNA (may differ from genome)Protein (295 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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-  Comments and Description Text from UniProtKB
  ID: ST1A3_HUMAN
DESCRIPTION: RecName: Full=Sulfotransferase 1A3/1A4; Short=ST1A3/ST1A4; EC=2.8.2.1; AltName: Full=Aryl sulfotransferase 1A3/1A4; AltName: Full=Catecholamine-sulfating phenol sulfotransferase; AltName: Full=HAST3; AltName: Full=M-PST; AltName: Full=Monoamine-sulfating phenol sulfotransferase; AltName: Full=Placental estrogen sulfotransferase; AltName: Full=Sulfotransferase, monoamine-preferring; AltName: Full=Thermolabile phenol sulfotransferase; Short=TL-PST;
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.
PTM: The N-terminus is blocked.
SIMILARITY: Belongs to the sulfotransferase 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.17 RPKM in Small Intestine - Terminal Ileum
Total median expression: 168.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.50104-0.226 Picture PostScript Text
3' UTR -126.20405-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain
PF13469 - Sulfotransferase family

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CJM - X-ray MuPIT 2A3R - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P50224
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC071688 - Homo sapiens cDNA clone IMAGE:5243747, **** WARNING: chimeric clone ****.
L19956 - Human aryl sulfotransferase mRNA, complete cds.
AK122707 - Homo sapiens cDNA FLJ16185 fis, clone BRTHA2005864, highly similar to Monoamine-sulfating phenol sulfotransferase (EC 2.8.2.1).
AK097386 - Homo sapiens cDNA FLJ40067 fis, clone TESOP2000527, moderately similar to MONOAMINE-SULFATING PHENOL SULFOTRANSFERASE (EC 2.8.2.1).
AK122733 - Homo sapiens cDNA FLJ16248 fis, clone HCHON2010543, highly similar to Human aryl sulfotransferase.
BC111011 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4, mRNA (cDNA clone MGC:117469 IMAGE:5768190), complete cds.
AK094769 - Homo sapiens cDNA FLJ37450 fis, clone BRAWH2010354, highly similar to Monoamine-sulfating phenol sulfotransferase (EC 2.8.2.1).
BC014471 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4, mRNA (cDNA clone MGC:23115 IMAGE:4907290), complete cds.
X84653 - H.sapiens mRNA for monoamine-sulfating phenosulfotransferase.
AK298073 - Homo sapiens cDNA FLJ54864 complete cds, highly similar to Monoamine-sulfating phenol sulfotransferase (EC 2.8.2.1).
BC144354 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:177891 IMAGE:9052874), complete cds.
BC132914 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:164545 IMAGE:40146936), complete cds.
BC132920 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:164551 IMAGE:40146942), complete cds.
BC144355 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:177892 IMAGE:9052875), complete cds.
BC171772 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:198487 IMAGE:9054426), complete cds.
JD192206 - Sequence 173230 from Patent EP1572962.
JD126364 - Sequence 107388 from Patent EP1572962.
L25275 - Homo sapiens estrogen sulfotransferase mRNA, complete cds.
JD374606 - Sequence 355630 from Patent EP1572962.
BC078144 - Homo sapiens sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3, mRNA (cDNA clone MGC:87931 IMAGE:6022425), complete cds.
U08032 - Human thermolabile (monoamine, M form) phenol sulfotransferase (STM) mRNA, complete cds.
AB528242 - Synthetic construct DNA, clone: pF1KE0559, Homo sapiens SULT1A4 gene for sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4, without stop codon, in Flexi system.
BC141504 - Synthetic construct Homo sapiens clone IMAGE:100014735, MGC:175358 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (SULT1A3) mRNA, encodes complete protein.
BC156739 - Synthetic construct Homo sapiens clone IMAGE:100062213, MGC:190206 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (SULT1A3) mRNA, encodes complete protein.
HQ258163 - Synthetic construct Homo sapiens clone IMAGE:100072472 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (SULT1A3), transcript variant 1 (SULT1A3) gene, encodes complete protein.
KJ892227 - Synthetic construct Homo sapiens clone ccsbBroadEn_01621 SULT1A3 gene, encodes complete protein.
CU677007 - Synthetic construct Homo sapiens gateway clone IMAGE:100023401 5' read SULT1A4 mRNA.
KJ897622 - Synthetic construct Homo sapiens clone ccsbBroadEn_07016 SULT1A3 gene, encodes complete protein.
AB111093 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*1A, complete cds.
AB111094 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*1A possible alternative splicing form, complete cds.
AB111095 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*2, complete cds.
AB111096 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*3, complete cds.
AB111097 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*4, complete cds.
AB111098 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*5, complete cds.
AB111099 - Homo sapiens ST1A5 mRNA for phenol sulfotransferase 1A5*1B, complete cds.
U34199 - Human aryl sulfotransferase mRNA, complete cds.
JD347545 - Sequence 328569 from Patent EP1572962.
JD451214 - Sequence 432238 from Patent EP1572962.
JD098864 - Sequence 79888 from Patent EP1572962.
JD376109 - Sequence 357133 from Patent EP1572962.
JD376110 - Sequence 357134 from Patent EP1572962.
JD543402 - Sequence 524426 from Patent EP1572962.
JD250249 - Sequence 231273 from Patent EP1572962.
JD252396 - Sequence 233420 from Patent EP1572962.
JD241829 - Sequence 222853 from Patent EP1572962.
JD564471 - Sequence 545495 from Patent EP1572962.
JD558369 - Sequence 539393 from Patent EP1572962.
JD441482 - Sequence 422506 from Patent EP1572962.
JD319654 - Sequence 300678 from Patent EP1572962.
JD545365 - Sequence 526389 from Patent EP1572962.
JD115300 - Sequence 96324 from Patent EP1572962.
JD274986 - Sequence 256010 from Patent EP1572962.
JD274987 - Sequence 256011 from Patent EP1572962.
JD079606 - Sequence 60630 from Patent EP1572962.
JD106641 - Sequence 87665 from Patent EP1572962.
JD145370 - Sequence 126394 from Patent EP1572962.
JD327159 - Sequence 308183 from Patent EP1572962.
JD561172 - Sequence 542196 from Patent EP1572962.
JD065970 - Sequence 46994 from Patent EP1572962.
JD206811 - Sequence 187835 from Patent EP1572962.
JD085337 - Sequence 66361 from Patent EP1572962.
JD093738 - Sequence 74762 from Patent EP1572962.
JD248733 - Sequence 229757 from Patent EP1572962.
JD104353 - Sequence 85377 from Patent EP1572962.
JD335390 - Sequence 316414 from Patent EP1572962.
JD457190 - Sequence 438214 from Patent EP1572962.
JD388428 - Sequence 369452 from Patent EP1572962.
JD118488 - Sequence 99512 from Patent EP1572962.
JD087869 - Sequence 68893 from Patent EP1572962.
JD438620 - Sequence 419644 from Patent EP1572962.
JD052690 - Sequence 33714 from Patent EP1572962.
JD378115 - Sequence 359139 from Patent EP1572962.
JD357566 - Sequence 338590 from Patent EP1572962.
JD101196 - Sequence 82220 from Patent EP1572962.
JD411238 - Sequence 392262 from Patent EP1572962.
JD105515 - Sequence 86539 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00920 - Sulfur metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B4DNV0, NM_177552, NP_808220, O95603, P50224, Q6ZWJ5, ST1A3_HUMAN, STM, SULT1A3
UCSC ID: uc002dtb.3
RefSeq Accession: NM_177552
Protein: P50224 (aka ST1A3_HUMAN or SUPM_HUMAN)
CCDS: CCDS32427.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_177552.3
exon count: 8CDS single in 3' UTR: no RNA size: 1408
ORF size: 888CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1976.00frame shift in genome: no % Coverage: 99.22
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.