Human Gene C15orf32 (uc002brc.1)
  Description: Homo sapiens chromosome 15 open reading frame 32 (C15orf32), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:93,014,907-93,044,347 Size: 29,441 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr15:93,015,379-93,043,630 Size: 28,252 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:93,014,907-93,044,347)mRNA (may differ from genome)Protein (178 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkH-INVHGNC
HPRDLynxMGIneXtProtPubMedTreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: CO032_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C15orf32;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C15orf32
CDC HuGE Published Literature: C15orf32
Positive Disease Associations: Alcoholism , Bipolar Disorder , Heart Rate , Respiratory Function Tests , Socioeconomic Factors , Vital Capacity
Related Studies:
  1. Alcoholism
    Andrew C Heath et al. Biological psychiatry 2011, A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications., Biological psychiatry. [PubMed 21529783]
    We conclude that 1) meta-analyses of consumption data may contribute usefully to gene discovery; 2) translation of human alcoholism GWAS results to drug discovery or clinically useful prediction of risk will be challenging; and 3) through accumulation across studies, GWAS data may become valuable for improved genetic risk differentiation in research in biological psychiatry (e.g., prospective high-risk or resilience studies).
  2. Bipolar Disorder
    M T M Lee et al. Molecular psychiatry 2011, Genome-wide association study of bipolar I disorder in the Han Chinese population., Molecular psychiatry. [PubMed 20386566]
  3. Heart Rate
    , , . [PubMed 0]
           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.14 RPKM in Testis
Total median expression: 1.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.32472-0.361 Picture PostScript Text
3' UTR -193.14717-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q32M92
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LP895987 - Sequence 851 from Patent EP3253886.
AK057393 - Homo sapiens cDNA FLJ32831 fis, clone TESTI2003193.
JD192088 - Sequence 173112 from Patent EP1572962.
JD071851 - Sequence 52875 from Patent EP1572962.
JD466269 - Sequence 447293 from Patent EP1572962.
JD439419 - Sequence 420443 from Patent EP1572962.
JD232916 - Sequence 213940 from Patent EP1572962.
JD563983 - Sequence 545007 from Patent EP1572962.
JD181567 - Sequence 162591 from Patent EP1572962.
BC109252 - Homo sapiens chromosome 15 open reading frame 32, mRNA (cDNA clone MGC:129836 IMAGE:40023840), complete cds.
BC109253 - Homo sapiens chromosome 15 open reading frame 32, mRNA (cDNA clone MGC:129837 IMAGE:40023844), complete cds.
JD422494 - Sequence 403518 from Patent EP1572962.
JD044992 - Sequence 26016 from Patent EP1572962.
JD112931 - Sequence 93955 from Patent EP1572962.
KJ903836 - Synthetic construct Homo sapiens clone ccsbBroadEn_13230 C15orf32 gene, encodes complete protein.
JD036725 - Sequence 17749 from Patent EP1572962.
JD284322 - Sequence 265346 from Patent EP1572962.
JD245310 - Sequence 226334 from Patent EP1572962.
JD485508 - Sequence 466532 from Patent EP1572962.
JD448396 - Sequence 429420 from Patent EP1572962.
JD364735 - Sequence 345759 from Patent EP1572962.
JD327413 - Sequence 308437 from Patent EP1572962.
JD321435 - Sequence 302459 from Patent EP1572962.
JD292859 - Sequence 273883 from Patent EP1572962.
JD327540 - Sequence 308564 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C5HTZ8, CO032_HUMAN, NM_153040, NP_694585, Q32M92, Q96M45
UCSC ID: uc002brc.1
RefSeq Accession: NM_153040
Protein: Q32M92 (aka CO032_HUMAN)
CCDS: CCDS10373.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_153040.2
exon count: 3CDS single in 3' UTR: no RNA size: 1726
ORF size: 537CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 388.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.