ID:RFNG_HUMAN DESCRIPTION: RecName: Full=Beta-1,3-N-acetylglucosaminyltransferase radical fringe; EC=2.4.1.222; AltName: Full=O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; FUNCTION: Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity). CATALYTIC ACTIVITY: Transfers a beta-D-GlcNAc residue from UDP-D- GlcNAc to the fucose residue of a fucosylated protein acceptor. COFACTOR: Manganese (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential). SIMILARITY: Belongs to the glycosyltransferase 31 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y644
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003674 molecular_function GO:0016740 transferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity GO:0046872 metal ion binding
Biological Process: GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0007399 nervous system development GO:0008593 regulation of Notch signaling pathway GO:0009887 animal organ morphogenesis GO:0030154 cell differentiation GO:0032092 positive regulation of protein binding GO:0036066 protein O-linked fucosylation GO:0045747 positive regulation of Notch signaling pathway
US Server
