Human Gene ADCK2 (uc003vvy.1)
  Description: Homo sapiens aarF domain containing kinase 2 (ADCK2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:140,372,953-140,394,908 Size: 21,956 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr7:140,373,131-140,394,603 Size: 21,473 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:140,372,953-140,394,908)mRNA (may differ from genome)Protein (626 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADCK2_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized aarF domain-containing protein kinase 2; EC=2.7.11.-;
FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ADCK2
CDC HuGE Published Literature: ADCK2
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.89 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 524.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.10178-0.602 Picture PostScript Text
3' UTR -118.10305-0.387 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004147 - UbiB_dom

Pfam Domains:
PF03109 - ABC1 family

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q7Z695
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
  Ensembl WormBaseSGD
  Protein Sequence Protein SequenceProtein Sequence
  Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY302592 - Homo sapiens putative ubiquinone biosynthesis protein AarF (AARF) mRNA, complete cds.
AF131745 - Homo sapiens clone 25110 mRNA sequence.
BC014107 - Homo sapiens aarF domain containing kinase 2, mRNA (cDNA clone MGC:20727 IMAGE:4138734), complete cds.
KJ903557 - Synthetic construct Homo sapiens clone ccsbBroadEn_12951 ADCK2 gene, encodes complete protein.
KJ905586 - Synthetic construct Homo sapiens clone ccsbBroadEn_15208 ADCK2 gene, encodes complete protein.
JD158176 - Sequence 139200 from Patent EP1572962.
JD399251 - Sequence 380275 from Patent EP1572962.
JD444010 - Sequence 425034 from Patent EP1572962.
JD408501 - Sequence 389525 from Patent EP1572962.
JD385299 - Sequence 366323 from Patent EP1572962.
JD376242 - Sequence 357266 from Patent EP1572962.
JD469024 - Sequence 450048 from Patent EP1572962.
JD455638 - Sequence 436662 from Patent EP1572962.
JD455507 - Sequence 436531 from Patent EP1572962.
JD418615 - Sequence 399639 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AARF, ADCK2_HUMAN, NM_052853, NP_443085, Q7Z695, Q96CN6, Q9Y6T5
UCSC ID: uc003vvy.1
RefSeq Accession: NM_052853
Protein: Q7Z695 (aka ADCK2_HUMAN)
CCDS: CCDS5861.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_052853.3
exon count: 8CDS single in 3' UTR: no RNA size: 2376
ORF size: 1881CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3902.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.