Description: Homo sapiens leukocyte cell-derived chemotaxin 2 (LECT2), mRNA. RefSeq Summary (NM_002302): This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:135,282,600-135,290,723 Size: 8,124 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:135,283,020-135,290,522 Size: 7,503 Coding Exon Count: 4
ID:LECT2_HUMAN DESCRIPTION: RecName: Full=Leukocyte cell-derived chemotaxin-2; Short=LECT-2; Short=hLECT2; Flags: Precursor; FUNCTION: Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. SUBCELLULAR LOCATION: Cytoplasm. Secreted. TISSUE SPECIFICITY: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow. INDUCTION: By phytohemagglutinin (PHA). SIMILARITY: Belongs to the LECT2/MIM-1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14960
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.