ID:ATMIN_HUMAN DESCRIPTION: RecName: Full=ATM interactor; AltName: Full=ATM/ATR-substrate CHK2-interacting zinc finger protein; Short=ASCIZ; AltName: Full=Zinc finger protein 822; FUNCTION: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. SUBUNIT: Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. SUBCELLULAR LOCATION: Nucleus. Note=Nuclear, in discrete foci during G1 phase. TISSUE SPECIFICITY: Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. SIMILARITY: Contains 2 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA24861.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF83632.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43313
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
