Description: Homo sapiens fructosamine 3 kinase related protein (FN3KRP), transcript variant 1, mRNA. RefSeq Summary (NM_024619): A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr17:80,674,582-80,685,893 Size: 11,312 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr17:80,674,632-80,685,047 Size: 10,416 Coding Exon Count: 6
ID:KT3K_HUMAN DESCRIPTION: RecName: Full=Ketosamine-3-kinase; EC=2.7.1.-; AltName: Full=Fructosamine-3-kinase-related protein; Short=FN3K-RP; Short=FN3K-related protein; FUNCTION: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation. TISSUE SPECIFICITY: Expressed in erythrocytes. SIMILARITY: Belongs to the fructosamine kinase family. SEQUENCE CAUTION: Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9HA64
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
