ID:NUMBL_HUMAN DESCRIPTION: RecName: Full=Numb-like protein; AltName: Full=Numb-related protein; Short=Numb-R; FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. SUBUNIT: Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1. INTERACTION: Q9NWB1:RBFOX1; NbExp=2; IntAct=EBI-945925, EBI-945906; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS (By similarity). DOMAIN: The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B. SIMILARITY: Contains 1 PID domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6R0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0019221 cytokine-mediated signaling pathway GO:0019538 protein metabolic process GO:0021670 lateral ventricle development GO:0021849 neuroblast division in subventricular zone GO:0030900 forebrain development GO:0034332 adherens junction organization GO:0050769 positive regulation of neurogenesis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
