Human Gene DCAF4 (uc010ttr.2)
Description: Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 5, mRNA.
RefSeq Summary (NM_001163509): This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009].
Transcript (Including UTRs)
Position: hg19 chr14:73,393,040-73,426,357 Size: 33,318 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr14:73,404,721-73,425,513 Size: 20,793 Coding Exon Count: 13
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom
Pfam Domains: PF00400 - WD domain, G-beta repeat
SCOP Domains: 50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain
ModBase Predicted Comparative 3D Structure on B4DN30
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
AK315499 - Homo sapiens cDNA, FLJ96563, highly similar to Homo sapiens WD repeat domain 21 (WDR21), mRNA.LF384867 - JP 2014500723-A/192370: Polycomb-Associated Non-Coding RNAs.BX161489 - human full-length cDNA clone CS0DJ006YD20 of T cells (Jurkat cell line) of Homo sapiens (human).AK297571 - Homo sapiens cDNA FLJ53137 complete cds, highly similar to WD repeat protein 21A.BC035901 - Homo sapiens WD repeat domain 21A, mRNA (cDNA clone MGC:46524 IMAGE:5241663), complete cds.AK300786 - Homo sapiens cDNA FLJ52764 complete cds, highly similar to WD repeat protein 21A.AK027745 - Homo sapiens cDNA FLJ14839 fis, clone OVARC1001791.AK297742 - Homo sapiens cDNA FLJ52699 complete cds, highly similar to WD repeat protein 21A.BX247962 - human full-length cDNA clone CS0DA010YD24 of Neuroblastoma of Homo sapiens (human).BC018979 - Homo sapiens WD repeat domain 21A, mRNA (cDNA clone MGC:20547 IMAGE:3604168), complete cds.MA620444 - JP 2018138019-A/192370: Polycomb-Associated Non-Coding RNAs.JD479407 - Sequence 460431 from Patent EP1572962.JD199145 - Sequence 180169 from Patent EP1572962.JD421142 - Sequence 402166 from Patent EP1572962.CU676348 - Synthetic construct Homo sapiens gateway clone IMAGE:100019671 5' read WDR21A mRNA.HQ448372 - Synthetic construct Homo sapiens clone IMAGE:100071796; CCSB006992_01 WD repeat domain 21A (WDR21A) gene, encodes complete protein.KJ898594 - Synthetic construct Homo sapiens clone ccsbBroadEn_07988 DCAF4 gene, encodes complete protein.AL080157 - Homo sapiens mRNA; cDNA DKFZp434K114 (from clone DKFZp434K114).JD191934 - Sequence 172958 from Patent EP1572962.LF329914 - JP 2014500723-A/137417: Polycomb-Associated Non-Coding RNAs.LF329915 - JP 2014500723-A/137418: Polycomb-Associated Non-Coding RNAs.JD102743 - Sequence 83767 from Patent EP1572962.HQ257934 - Synthetic construct Homo sapiens clone IMAGE:100072243 DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 2 (DCAF4) gene, encodes complete protein.KJ898595 - Synthetic construct Homo sapiens clone ccsbBroadEn_07989 DCAF4 gene, encodes complete protein.LF329918 - JP 2014500723-A/137421: Polycomb-Associated Non-Coding RNAs.LF329919 - JP 2014500723-A/137422: Polycomb-Associated Non-Coding RNAs.LF329920 - JP 2014500723-A/137423: Polycomb-Associated Non-Coding RNAs.LF329921 - JP 2014500723-A/137424: Polycomb-Associated Non-Coding RNAs.LF329922 - JP 2014500723-A/137425: Polycomb-Associated Non-Coding RNAs.JD147907 - Sequence 128931 from Patent EP1572962.JD552516 - Sequence 533540 from Patent EP1572962.JD302306 - Sequence 283330 from Patent EP1572962.JD301830 - Sequence 282854 from Patent EP1572962.JD201203 - Sequence 182227 from Patent EP1572962.JD163945 - Sequence 144969 from Patent EP1572962.JD333413 - Sequence 314437 from Patent EP1572962.JD187805 - Sequence 168829 from Patent EP1572962.JD068231 - Sequence 49255 from Patent EP1572962.JD417187 - Sequence 398211 from Patent EP1572962.MA565491 - JP 2018138019-A/137417: Polycomb-Associated Non-Coding RNAs.MA565492 - JP 2018138019-A/137418: Polycomb-Associated Non-Coding RNAs.MA565495 - JP 2018138019-A/137421: Polycomb-Associated Non-Coding RNAs.MA565496 - JP 2018138019-A/137422: Polycomb-Associated Non-Coding RNAs.MA565497 - JP 2018138019-A/137423: Polycomb-Associated Non-Coding RNAs.MA565498 - JP 2018138019-A/137424: Polycomb-Associated Non-Coding RNAs.MA565499 - JP 2018138019-A/137425: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001163509.1
exon count:
14 CDS single in 3' UTR:
no
RNA size:
2539
ORF size:
1425 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2992.00 frame shift in genome:
no
% Coverage:
99.37
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.