Human Gene TP53I11 (uc001myk.3)
  Description: Homo sapiens tumor protein p53 inducible protein 11 (TP53I11), transcript variant 6, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:44,953,899-44,972,608 Size: 18,710 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr11:44,956,435-44,959,886 Size: 3,452 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:44,953,899-44,972,608)mRNA (may differ from genome)Protein (189 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P5I11_HUMAN
DESCRIPTION: RecName: Full=Tumor protein p53-inducible protein 11; AltName: Full=p53-induced gene 11 protein;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
INDUCTION: By p53/TP53.
SEQUENCE CAUTION: Sequence=AAC39533.1; Type=Miscellaneous discrepancy; Note=Localized in an untranslated region: wrong choice of CDS;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TP53I11
CDC HuGE Published Literature: TP53I11
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.86 RPKM in Adipose - Visceral (Omentum)
Total median expression: 128.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -225.32412-0.547 Picture PostScript Text
3' UTR -1080.062536-0.426 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14936 - Tumour protein p53-inducible protein 11

ModBase Predicted Comparative 3D Structure on O14683
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008285 negative regulation of cell proliferation

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK026607 - Homo sapiens cDNA: FLJ22954 fis, clone KAT09813, highly similar to AF010315 Homo sapiens Pig11 (PIG11) mRNA.
U79302 - Human clone 23855 mRNA, partial cds.
AK056379 - Homo sapiens cDNA FLJ31817 fis, clone NT2RP6000008, moderately similar to Homo sapiens Pig11 (PIG11) mRNA.
AK054815 - Homo sapiens cDNA FLJ30253 fis, clone BRACE2002431, moderately similar to P53-INDUCED PROTEIN 11.
AK096176 - Homo sapiens cDNA FLJ38857 fis, clone MESAN2011597.
BC045666 - Homo sapiens tumor protein p53 inducible protein 11, mRNA (cDNA clone MGC:44491 IMAGE:5298525), complete cds.
BC071606 - Homo sapiens tumor protein p53 inducible protein 11, mRNA (cDNA clone IMAGE:4822518), partial cds.
AK292837 - Homo sapiens cDNA FLJ76159 complete cds, highly similar to Homo sapiens tumor protein p53 inducible protein 11 (TP53I11), mRNA.
AB587371 - Synthetic construct DNA, clone: pF1KB4576, Homo sapiens TP53I11 gene for tumor protein p53 inducible protein 11, without stop codon, in Flexi system.
AF010315 - Homo sapiens Pig11 (PIG11) mRNA, complete cds.
BC000443 - Homo sapiens tumor protein p53 inducible protein 11, mRNA (cDNA clone IMAGE:2820767).
BC003010 - Homo sapiens tumor protein p53 inducible protein 11, mRNA (cDNA clone IMAGE:2820767).
BC065557 - Homo sapiens tumor protein p53 inducible protein 11, mRNA (cDNA clone IMAGE:6138729).
JD094313 - Sequence 75337 from Patent EP1572962.
JD252891 - Sequence 233915 from Patent EP1572962.
JD124023 - Sequence 105047 from Patent EP1572962.
JD406377 - Sequence 387401 from Patent EP1572962.
JD497029 - Sequence 478053 from Patent EP1572962.
JD051909 - Sequence 32933 from Patent EP1572962.
JD481818 - Sequence 462842 from Patent EP1572962.
JD080562 - Sequence 61586 from Patent EP1572962.
JD466103 - Sequence 447127 from Patent EP1572962.
JD272800 - Sequence 253824 from Patent EP1572962.
KJ901991 - Synthetic construct Homo sapiens clone ccsbBroadEn_11385 TP53I11 gene, encodes complete protein.
CU688072 - Synthetic construct Homo sapiens gateway clone IMAGE:100021556 5' read TP53I11 mRNA.
JD126254 - Sequence 107278 from Patent EP1572962.
JD054012 - Sequence 35036 from Patent EP1572962.
JD056204 - Sequence 37228 from Patent EP1572962.
JD162532 - Sequence 143556 from Patent EP1572962.
JD054012 - Sequence 35036 from Patent EP1572962.
JD056204 - Sequence 37228 from Patent EP1572962.
JD117409 - Sequence 98433 from Patent EP1572962.
JD209184 - Sequence 190208 from Patent EP1572962.
JD137618 - Sequence 118642 from Patent EP1572962.
JD381433 - Sequence 362457 from Patent EP1572962.
JD060703 - Sequence 41727 from Patent EP1572962.
JD280115 - Sequence 261139 from Patent EP1572962.
JD189042 - Sequence 170066 from Patent EP1572962.
JD404737 - Sequence 385761 from Patent EP1572962.
JD050395 - Sequence 31419 from Patent EP1572962.
JD097236 - Sequence 78260 from Patent EP1572962.
JD097154 - Sequence 78178 from Patent EP1572962.
JD097120 - Sequence 78144 from Patent EP1572962.
JD526784 - Sequence 507808 from Patent EP1572962.
JD077852 - Sequence 58876 from Patent EP1572962.
JD311285 - Sequence 292309 from Patent EP1572962.
JD156090 - Sequence 137114 from Patent EP1572962.
JD392785 - Sequence 373809 from Patent EP1572962.
JD399636 - Sequence 380660 from Patent EP1572962.
JD399637 - Sequence 380661 from Patent EP1572962.
JD399639 - Sequence 380663 from Patent EP1572962.
JD136526 - Sequence 117550 from Patent EP1572962.
JD383612 - Sequence 364636 from Patent EP1572962.
JD399652 - Sequence 380676 from Patent EP1572962.
JD394964 - Sequence 375988 from Patent EP1572962.
JD394953 - Sequence 375977 from Patent EP1572962.
JD056102 - Sequence 37126 from Patent EP1572962.
JD204994 - Sequence 186018 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006034, NP_006025, O14683, P5I11_HUMAN, PIG11, Q3ZCS0
UCSC ID: uc001myk.3
RefSeq Accession: NM_006034
Protein: O14683 (aka P5I11_HUMAN)
CCDS: CCDS7911.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006034.3
exon count: 7CDS single in 3' UTR: no RNA size: 3518
ORF size: 570CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 1200.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.