Human Gene ZNF460 (uc002qog.2)
  Description: Homo sapiens zinc finger protein 460 (ZNF460), mRNA.
RefSeq Summary (NM_006635): Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004].
Transcript (Including UTRs)
   Position: hg19 chr19:57,791,853-57,805,436 Size: 13,584 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:57,792,175-57,803,598 Size: 11,424 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,791,853-57,805,436)mRNA (may differ from genome)Protein (562 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN460_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 460; AltName: Full=Zinc finger protein 272; AltName: Full=Zinc finger protein HZF8;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.96 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 33.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -155.19322-0.482 Picture PostScript Text
3' UTR -472.631838-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q14592
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK298106 - Homo sapiens cDNA FLJ56994 complete cds, highly similar to Zinc finger protein 460.
AK292144 - Homo sapiens cDNA FLJ76922 complete cds, highly similar to Homo sapiens zinc finger protein 272 (ZNF272), mRNA.
AK074582 - Homo sapiens cDNA FLJ90101 fis, clone HEMBA1006276, weakly similar to ZINC FINGER PROTEIN 90.
AY329492 - Homo sapiens zinc finger-like protein mRNA, complete cds.
BC109018 - Homo sapiens zinc finger protein 460, mRNA (cDNA clone IMAGE:40006197), partial cds.
BC109019 - Homo sapiens zinc finger protein 460, mRNA (cDNA clone IMAGE:40006200), partial cds.
KJ893134 - Synthetic construct Homo sapiens clone ccsbBroadEn_02528 ZNF460 gene, encodes complete protein.
BC118625 - Homo sapiens zinc finger protein 272, mRNA (cDNA clone MGC:125328 IMAGE:40006201), complete cds.
JD366805 - Sequence 347829 from Patent EP1572962.
JD305867 - Sequence 286891 from Patent EP1572962.
AK090816 - Homo sapiens cDNA FLJ33497 fis, clone BRAMY2004058.
AX746630 - Sequence 155 from Patent EP1308459.
JD204336 - Sequence 185360 from Patent EP1572962.
X78931 - H.sapiens HZF8 mRNA for zinc finger protein.
JD047389 - Sequence 28413 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD047389 - Sequence 28413 from Patent EP1572962.
JD442415 - Sequence 423439 from Patent EP1572962.
JD054197 - Sequence 35221 from Patent EP1572962.
JD122669 - Sequence 103693 from Patent EP1572962.
JD037113 - Sequence 18137 from Patent EP1572962.
JD553897 - Sequence 534921 from Patent EP1572962.
JD303254 - Sequence 284278 from Patent EP1572962.
JD349309 - Sequence 330333 from Patent EP1572962.
JD042478 - Sequence 23502 from Patent EP1572962.
JD361398 - Sequence 342422 from Patent EP1572962.
JD249125 - Sequence 230149 from Patent EP1572962.
JD167687 - Sequence 148711 from Patent EP1572962.
JD347987 - Sequence 329011 from Patent EP1572962.
JD509340 - Sequence 490364 from Patent EP1572962.
JD226031 - Sequence 207055 from Patent EP1572962.
JD433419 - Sequence 414443 from Patent EP1572962.
JD299704 - Sequence 280728 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14592 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A4FU64, NM_006635, NP_006626, Q14592, Q2VPC7, Q6VSF8, ZN460_HUMAN, ZNF272
UCSC ID: uc002qog.2
RefSeq Accession: NM_006635
Protein: Q14592 (aka ZN460_HUMAN)
CCDS: CCDS12949.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006635.3
exon count: 3CDS single in 3' UTR: no RNA size: 3849
ORF size: 1689CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3578.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.