Description: Homo sapiens death inducer-obliterator 1 (DIDO1), transcript variant 5, mRNA. RefSeq Summary (NM_001193369): Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:61,509,090-61,557,903 Size: 48,814 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr20:61,510,585-61,542,964 Size: 32,380 Coding Exon Count: 14
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DIDO1 CDC HuGE Published Literature: DIDO1 Positive Disease Associations: migraine Related Studies:
migraine Mochi, M. et al. 2003, A genetic association study of migraine with dopamine receptor 4, dopamine transporter and dopamine-beta-hydroxylase genes., Neurological sciences. 2003 Feb;23(6):301-5.
[PubMed 12624717]
Our data indicate that MO, but not MA, shows significant genetic association with DRD4.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
