Human Gene KIF18B (uc010wjh.3)
  Description: Homo sapiens kinesin family member 18B (KIF18B), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:43,002,079-43,025,079 Size: 23,001 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr17:43,003,448-43,013,712 Size: 10,265 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:43,002,079-43,025,079)mRNA (may differ from genome)Protein (852 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.23 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 30.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.8098-0.416 Picture PostScript Text
3' UTR -467.411369-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q86Y91-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  DQ595941 - Homo sapiens piRNA piR-62053, complete sequence.
BC048263 - Homo sapiens hypothetical protein LOC146909, mRNA (cDNA clone IMAGE:4418755), partial cds.
BC067365 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone IMAGE:4587138), partial cds.
BC044933 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone IMAGE:4540326), partial cds.
JD545858 - Sequence 526882 from Patent EP1572962.
JD178308 - Sequence 159332 from Patent EP1572962.
JD318087 - Sequence 299111 from Patent EP1572962.
JD275836 - Sequence 256860 from Patent EP1572962.
JD474290 - Sequence 455314 from Patent EP1572962.
JD125376 - Sequence 106400 from Patent EP1572962.
JD119379 - Sequence 100403 from Patent EP1572962.
JD196972 - Sequence 177996 from Patent EP1572962.
JD116533 - Sequence 97557 from Patent EP1572962.
JD285474 - Sequence 266498 from Patent EP1572962.
JD272333 - Sequence 253357 from Patent EP1572962.
JD064306 - Sequence 45330 from Patent EP1572962.
JD237803 - Sequence 218827 from Patent EP1572962.
JD285420 - Sequence 266444 from Patent EP1572962.
JD285419 - Sequence 266443 from Patent EP1572962.
JD072212 - Sequence 53236 from Patent EP1572962.
JD499753 - Sequence 480777 from Patent EP1572962.
JD426771 - Sequence 407795 from Patent EP1572962.
JD489177 - Sequence 470201 from Patent EP1572962.
JD374550 - Sequence 355574 from Patent EP1572962.
JD489176 - Sequence 470200 from Patent EP1572962.
JD409296 - Sequence 390320 from Patent EP1572962.
JD321969 - Sequence 302993 from Patent EP1572962.
JD515264 - Sequence 496288 from Patent EP1572962.
JD119360 - Sequence 100384 from Patent EP1572962.
JD301281 - Sequence 282305 from Patent EP1572962.
JD288702 - Sequence 269726 from Patent EP1572962.
JD160624 - Sequence 141648 from Patent EP1572962.
JD273155 - Sequence 254179 from Patent EP1572962.
JD173056 - Sequence 154080 from Patent EP1572962.
JD203446 - Sequence 184470 from Patent EP1572962.
BC136590 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone MGC:168203 IMAGE:9020580), complete cds.
BC144271 - Homo sapiens kinesin family member 18B, mRNA (cDNA clone MGC:177808 IMAGE:9052791), complete cds.
JD220599 - Sequence 201623 from Patent EP1572962.
JD111120 - Sequence 92144 from Patent EP1572962.
GU808359 - Homo sapiens cell-line HeLa KIF18B mRNA, complete cds.
JD065058 - Sequence 46082 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86Y91 (Reactome details) participates in the following event(s):

R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-109582 Hemostasis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001265577, NP_001252506, Q86Y91-3, uc010wjh.2
UCSC ID: uc010wjh.3
RefSeq Accession: NM_001265577
Protein: Q86Y91-3 CCDS: CCDS58555.1, CCDS45709.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001265577.1
exon count: 16CDS single in 3' UTR: no RNA size: 4045
ORF size: 2559CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5318.00frame shift in genome: no % Coverage: 99.53
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.