Human Gene ZBTB7C (uc002ldb.3)
Description: Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C), mRNA.Transcript (Including UTRs) Position: hg19 chr18:45,553,639-45,663,680 Size: 110,042 Total Exon Count: 3 Strand: -Coding Region Position: hg19 chr18:45,555,631-45,567,478 Size: 11,848 Coding Exon Count: 2
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ZBT7C_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 7C; AltName: Full=Affected by papillomavirus DNA integration in ME180 cells protein 1; Short=APM-1; AltName: Full=Zinc finger and BTB domain-containing protein 36; AltName: Full=Zinc finger protein 857C;FUNCTION: May be a tumor suppressor gene.TISSUE SPECIFICITY: Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.SIMILARITY: Contains 1 BTB (POZ) domain.SIMILARITY: Contains 4 C2H2-type zinc fingers.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ZBTB7C
CDC HuGE Published Literature: ZBTB7C
Positive Disease Associations: Arteries
Related Studies: Arteries 0 ]
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000210 - BTB/POZ-likeIPR011333 - BTB/POZ_foldIPR013069 - BTB_POZIPR007087 - Znf_C2H2IPR015880 - Znf_C2H2-likeIPR013087 - Znf_C2H2/integrase_DNA-bdPfam Domains: PF00096 - Zinc finger, C2H2 typePF00651 - BTB/POZ domainPF12874 - Zinc-finger of C2H2 typePF13912 - C2H2-type zinc fingerSCOP Domains: 54695 - POZ domain57667 - C2H2 and C2HC zinc fingersModBase Predicted Comparative 3D Structure on A1YPR0 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog Gene Details Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:0003674 molecular_functionGO:0003676 nucleic acid bindingGO:0046872 metal ion bindingBiological Process: GO:0008285 negative regulation of cell proliferationGO:0045600 positive regulation of fat cell differentiationGO:0045944 positive regulation of transcription from RNA polymerase II promoterGO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA bindingCellular Component: GO:0005575 cellular_componentGO:0005634 nucleus
Descriptions from all associated GenBank mRNAs
AM988836 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-391.1.AM988837 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.1.AM988838 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.2.AM988839 - Homo sapiens mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.1.AK296709 - Homo sapiens cDNA FLJ60286 complete cds, highly similar to Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C), mRNA.EF120357 - Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C) mRNA, complete cds.AM998488 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.1.AM998489 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-394.3.AM998476 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.1.AM998477 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.2.AM998478 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.3.AM998479 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.4.AM998480 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.5.AM998481 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.6.AM998482 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.7.AM998483 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.8.AM998484 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.9.AM998485 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.10.AM998486 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.11.AM998487 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u2.12.AM991276 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.1.AM991277 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.2.AM991278 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.3.AM991279 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.4.1.AM991280 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.4.2.AM991281 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.5.AM991282 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.6.AM991283 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.7.AM991284 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.8.AM991285 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-418.9.AM989327 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-398.1.AM989331 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.EU669438 - Homo sapiens zinc finger and BTB domain-containing 7C (ZBTB7C) mRNA, partial cds.AM989329 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.1.AM989330 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.AM989328 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-419.1.AM991959 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.1.AM991960 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.1.AM991961 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.2.2.AM991962 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.1.AM991963 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.3.2.AM991964 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.4.AM991965 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.5.AM991966 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.6.AM991967 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.7.AM991968 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.8.AM991969 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.9.AM991970 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-415.10.AK095226 - Homo sapiens cDNA FLJ37907 fis, clone COLON2009337.JD122507 - Sequence 103531 from Patent EP1572962.JD295668 - Sequence 276692 from Patent EP1572962.JD398071 - Sequence 379095 from Patent EP1572962.JD412282 - Sequence 393306 from Patent EP1572962.JD533615 - Sequence 514639 from Patent EP1572962.JD040299 - Sequence 21323 from Patent EP1572962.JD099854 - Sequence 80878 from Patent EP1572962.JD284343 - Sequence 265367 from Patent EP1572962.JD428893 - Sequence 409917 from Patent EP1572962.JD356183 - Sequence 337207 from Patent EP1572962.JD375766 - Sequence 356790 from Patent EP1572962.JD270742 - Sequence 251766 from Patent EP1572962.JD394485 - Sequence 375509 from Patent EP1572962.JD458793 - Sequence 439817 from Patent EP1572962.JD156358 - Sequence 137382 from Patent EP1572962.JD323462 - Sequence 304486 from Patent EP1572962.JD463642 - Sequence 444666 from Patent EP1572962.JD438343 - Sequence 419367 from Patent EP1572962.JD469057 - Sequence 450081 from Patent EP1572962.JD539164 - Sequence 520188 from Patent EP1572962.JD550510 - Sequence 531534 from Patent EP1572962.JD359372 - Sequence 340396 from Patent EP1572962.JD126603 - Sequence 107627 from Patent EP1572962.JD473150 - Sequence 454174 from Patent EP1572962.JD114976 - Sequence 96000 from Patent EP1572962.JD471039 - Sequence 452063 from Patent EP1572962.JD125862 - Sequence 106886 from Patent EP1572962.JD209880 - Sequence 190904 from Patent EP1572962.JD115549 - Sequence 96573 from Patent EP1572962.JD464093 - Sequence 445117 from Patent EP1572962.JD127478 - Sequence 108502 from Patent EP1572962.BC167847 - Synthetic construct Homo sapiens clone IMAGE:100068237, MGC:195854 zinc finger and BTB domain containing 7C (ZBTB7C) mRNA, encodes complete protein.AM989332 - Homo sapiens partial mRNA for zinc finger and BTB domain containing 7C (ZBTB7C gene), 5'-UTR variant u1-385.1.
Other Names for This Gene
Alternate Gene Symbols: A1YPR0, APM1, NM_001039360, NP_001034449, O73453, ZBT7C_HUMAN, ZBTB36, ZNF857CUCSC ID: uc002ldb.3RefSeq Accession: NM_001039360 Protein: A1YPR0
(aka ZBT7C_HUMAN)CCDS: CCDS32830.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001039360.2
exon count:
3 CDS single in 3' UTR:
no
RNA size:
4188 ORF size:
1860 CDS single in intron:
no
Alignment % ID:
100.00 txCdsPredict score:
3839.50 frame shift in genome:
no
% Coverage:
99.59 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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