Human Gene C8orf33 (uc003zfc.4)
  Description: Homo sapiens chromosome 8 open reading frame 33 (C8orf33), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:146,277,824-146,281,416 Size: 3,593 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr8:146,277,878-146,279,543 Size: 1,666 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:146,277,824-146,281,416)mRNA (may differ from genome)Protein (229 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CH033_HUMAN
DESCRIPTION: RecName: Full=UPF0488 protein C8orf33;
SIMILARITY: Belongs to the UPF0488 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.74 RPKM in Adrenal Gland
Total median expression: 958.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.2054-0.393 Picture PostScript Text
3' UTR -646.101873-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15393 - Domain of unknown function (DUF4615)

ModBase Predicted Comparative 3D Structure on Q9H7E9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  AK024642 - Homo sapiens cDNA: FLJ20989 fis, clone CAE01644.
BX648996 - Homo sapiens mRNA; cDNA DKFZp686O2184 (from clone DKFZp686O2184).
BC010001 - Homo sapiens chromosome 8 open reading frame 33, mRNA (cDNA clone MGC:14956 IMAGE:4135341), complete cds.
JD187952 - Sequence 168976 from Patent EP1572962.
KJ894605 - Synthetic construct Homo sapiens clone ccsbBroadEn_03999 C8orf33 gene, encodes complete protein.
CR457330 - Homo sapiens full open reading frame cDNA clone RZPDo834H129D for gene FLJ20989, hypothetical protein FLJ20989; complete cds, incl. stopcodon.
BC015181 - Homo sapiens chromosome 8 open reading frame 33, mRNA (cDNA clone IMAGE:3906149), partial cds.
AF086170 - Homo sapiens full length insert cDNA clone ZB85G04.
DQ592456 - Homo sapiens piRNA piR-59568, complete sequence.
JD503304 - Sequence 484328 from Patent EP1572962.
JD300538 - Sequence 281562 from Patent EP1572962.
JD199100 - Sequence 180124 from Patent EP1572962.
JD073968 - Sequence 54992 from Patent EP1572962.
JD309067 - Sequence 290091 from Patent EP1572962.
JD023257 - Sequence 4281 from Patent EP1572962.
JD025838 - Sequence 6862 from Patent EP1572962.
JD550426 - Sequence 531450 from Patent EP1572962.
JD453540 - Sequence 434564 from Patent EP1572962.
JD035333 - Sequence 16357 from Patent EP1572962.
JD019005 - Sequence 29 from Patent EP1572962.
JD030382 - Sequence 11406 from Patent EP1572962.
JD030373 - Sequence 11397 from Patent EP1572962.
JD536518 - Sequence 517542 from Patent EP1572962.
JD365494 - Sequence 346518 from Patent EP1572962.
JD433632 - Sequence 414656 from Patent EP1572962.
JD312316 - Sequence 293340 from Patent EP1572962.
JD331296 - Sequence 312320 from Patent EP1572962.
JD194112 - Sequence 175136 from Patent EP1572962.
JD449453 - Sequence 430477 from Patent EP1572962.
JD511885 - Sequence 492909 from Patent EP1572962.
JD440427 - Sequence 421451 from Patent EP1572962.
DQ579581 - Homo sapiens piRNA piR-47693, complete sequence.
JD368870 - Sequence 349894 from Patent EP1572962.
JD554336 - Sequence 535360 from Patent EP1572962.
JD401325 - Sequence 382349 from Patent EP1572962.
JD418802 - Sequence 399826 from Patent EP1572962.
JD261044 - Sequence 242068 from Patent EP1572962.
JD304639 - Sequence 285663 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NGC0, CH033_HUMAN, NM_023080, NP_075568, Q96BT8, Q9H7E9
UCSC ID: uc003zfc.4
RefSeq Accession: NM_023080
Protein: Q9H7E9 (aka CH033_HUMAN)
CCDS: CCDS34974.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_023080.2
exon count: 5CDS single in 3' UTR: no RNA size: 2617
ORF size: 690CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1580.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.