ID:FGD5_HUMAN DESCRIPTION: RecName: Full=FYVE, RhoGEF and PH domain-containing protein 5; AltName: Full=Zinc finger FYVE domain-containing protein 23; FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F- actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5. TISSUE SPECIFICITY: Expressed in endothelial cells (at protein level). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 2 PH domains. SEQUENCE CAUTION: Sequence=BAC04878.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC04989.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC85128.1; Type=Frameshift; Positions=79; Sequence=CAD98090.1; Type=Erroneous termination; Positions=1279; Note=Translated as Lys;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZNL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
