Description: Homo sapiens Rho guanine nucleotide exchange factor (GEF) 5 (ARHGEF5), mRNA. RefSeq Summary (NM_005435): Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:144,052,489-144,077,725 Size: 25,237 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr7:144,059,763-144,077,149 Size: 17,387 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12774
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002408 myeloid dendritic cell chemotaxis GO:0007186 G-protein coupled receptor signaling pathway GO:0030036 actin cytoskeleton organization GO:0032956 regulation of actin cytoskeleton organization GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0043087 regulation of GTPase activity GO:0043507 positive regulation of JUN kinase activity GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051493 regulation of cytoskeleton organization GO:0051496 positive regulation of stress fiber assembly GO:0071803 positive regulation of podosome assembly GO:1904591 positive regulation of protein import GO:0070372 regulation of ERK1 and ERK2 cascade
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