Description: Homo sapiens BCL2-associated athanogene 2 (BAG2), mRNA. RefSeq Summary (NM_004282): BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:57,037,104-57,050,012 Size: 12,909 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr6:57,037,496-57,048,988 Size: 11,493 Coding Exon Count: 3
ID:BAG2_HUMAN DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 2; Short=BAG-2; AltName: Full=Bcl-2-associated athanogene 2; FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones. SIMILARITY: Contains 1 BAG domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95816
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0010954 positive regulation of protein processing GO:0019538 protein metabolic process GO:0031397 negative regulation of protein ubiquitination GO:0032091 negative regulation of protein binding GO:0050821 protein stabilization GO:1900034 regulation of cellular response to heat GO:1901800 positive regulation of proteasomal protein catabolic process GO:1904667 negative regulation of ubiquitin protein ligase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
AK001015 - Homo sapiens cDNA FLJ10153 fis, clone HEMBA1003417, highly similar to BAG family molecular chaperone regulator 2. AK023735 - Homo sapiens cDNA FLJ13673 fis, clone PLACE1011858, highly similar to BAG family molecular chaperone regulator 2. AF095192 - Homo sapiens BAG-family molecular chaperone regulator-2 mRNA, complete cds. LF205173 - JP 2014500723-A/12676: Polycomb-Associated Non-Coding RNAs. AL050287 - Homo sapiens mRNA; cDNA DKFZp586C021 (from clone DKFZp586C021). JD495530 - Sequence 476554 from Patent EP1572962. JD470786 - Sequence 451810 from Patent EP1572962. JD472989 - Sequence 454013 from Patent EP1572962. BC125039 - Homo sapiens BCL2-associated athanogene 2, mRNA (cDNA clone MGC:149462 IMAGE:40115422), complete cds. KJ892792 - Synthetic construct Homo sapiens clone ccsbBroadEn_02186 BAG2 gene, encodes complete protein. AB462960 - Synthetic construct DNA, clone: pF1KB8400, Homo sapiens BAG2 gene for BCL2-associated athanogene 2, without stop codon, in Flexi system. AM392695 - Synthetic construct Homo sapiens clone IMAGE:100001687 for hypothetical protein (BAG2 gene). AM393005 - Synthetic construct Homo sapiens clone IMAGE:100001689 for hypothetical protein (BAG2 gene). CR533496 - Homo sapiens full open reading frame cDNA clone RZPDo834G0217D for gene BAG2, BCL2-associated athanogene 2; complete cds, incl. stopcodon. AK301934 - Homo sapiens cDNA FLJ50277 complete cds, highly similar to BAG family molecular chaperone regulator 2. LF205174 - JP 2014500723-A/12677: Polycomb-Associated Non-Coding RNAs. LF317255 - JP 2014500723-A/124758: Polycomb-Associated Non-Coding RNAs. JD262329 - Sequence 243353 from Patent EP1572962. JD146307 - Sequence 127331 from Patent EP1572962. LF317254 - JP 2014500723-A/124757: Polycomb-Associated Non-Coding RNAs. JD530249 - Sequence 511273 from Patent EP1572962. JD186708 - Sequence 167732 from Patent EP1572962. JD050287 - Sequence 31311 from Patent EP1572962. JD563259 - Sequence 544283 from Patent EP1572962. LF317253 - JP 2014500723-A/124756: Polycomb-Associated Non-Coding RNAs. MA440750 - JP 2018138019-A/12676: Polycomb-Associated Non-Coding RNAs. MA440751 - JP 2018138019-A/12677: Polycomb-Associated Non-Coding RNAs. MA552832 - JP 2018138019-A/124758: Polycomb-Associated Non-Coding RNAs. MA552831 - JP 2018138019-A/124757: Polycomb-Associated Non-Coding RNAs. MA552830 - JP 2018138019-A/124756: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95816 (Reactome details) participates in the following event(s):
R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli