Human Gene BAG2 (uc003pdr.3)
  Description: Homo sapiens BCL2-associated athanogene 2 (BAG2), mRNA.
RefSeq Summary (NM_004282): BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:57,037,104-57,050,012 Size: 12,909 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr6:57,037,496-57,048,988 Size: 11,493 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:57,037,104-57,050,012)mRNA (may differ from genome)Protein (211 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BAG2_HUMAN
DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 2; Short=BAG-2; AltName: Full=Bcl-2-associated athanogene 2;
FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones.
SIMILARITY: Contains 1 BAG domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: BAG2
Diseases sorted by gene-association score: spindle cell hemangioma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.21 RPKM in Bladder
Total median expression: 175.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -199.40392-0.509 Picture PostScript Text
3' UTR -222.061024-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003103 - BAG_domain

ModBase Predicted Comparative 3D Structure on O95816
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0044325 ion channel binding
GO:0048156 tau protein binding
GO:0051087 chaperone binding

Biological Process:
GO:0006457 protein folding
GO:0010954 positive regulation of protein processing
GO:0019538 protein metabolic process
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0050821 protein stabilization
GO:1900034 regulation of cellular response to heat
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Cellular Component:
GO:0005829 cytosol
GO:0005874 microtubule
GO:0030424 axon
GO:0030425 dendrite
GO:1901588 dendritic microtubule


-  Descriptions from all associated GenBank mRNAs
  AK001015 - Homo sapiens cDNA FLJ10153 fis, clone HEMBA1003417, highly similar to BAG family molecular chaperone regulator 2.
AK023735 - Homo sapiens cDNA FLJ13673 fis, clone PLACE1011858, highly similar to BAG family molecular chaperone regulator 2.
AF095192 - Homo sapiens BAG-family molecular chaperone regulator-2 mRNA, complete cds.
LF205173 - JP 2014500723-A/12676: Polycomb-Associated Non-Coding RNAs.
AL050287 - Homo sapiens mRNA; cDNA DKFZp586C021 (from clone DKFZp586C021).
JD495530 - Sequence 476554 from Patent EP1572962.
JD470786 - Sequence 451810 from Patent EP1572962.
JD472989 - Sequence 454013 from Patent EP1572962.
BC125039 - Homo sapiens BCL2-associated athanogene 2, mRNA (cDNA clone MGC:149462 IMAGE:40115422), complete cds.
KJ892792 - Synthetic construct Homo sapiens clone ccsbBroadEn_02186 BAG2 gene, encodes complete protein.
AB462960 - Synthetic construct DNA, clone: pF1KB8400, Homo sapiens BAG2 gene for BCL2-associated athanogene 2, without stop codon, in Flexi system.
AM392695 - Synthetic construct Homo sapiens clone IMAGE:100001687 for hypothetical protein (BAG2 gene).
AM393005 - Synthetic construct Homo sapiens clone IMAGE:100001689 for hypothetical protein (BAG2 gene).
CR533496 - Homo sapiens full open reading frame cDNA clone RZPDo834G0217D for gene BAG2, BCL2-associated athanogene 2; complete cds, incl. stopcodon.
AK301934 - Homo sapiens cDNA FLJ50277 complete cds, highly similar to BAG family molecular chaperone regulator 2.
LF205174 - JP 2014500723-A/12677: Polycomb-Associated Non-Coding RNAs.
LF317255 - JP 2014500723-A/124758: Polycomb-Associated Non-Coding RNAs.
JD262329 - Sequence 243353 from Patent EP1572962.
JD146307 - Sequence 127331 from Patent EP1572962.
LF317254 - JP 2014500723-A/124757: Polycomb-Associated Non-Coding RNAs.
JD530249 - Sequence 511273 from Patent EP1572962.
JD186708 - Sequence 167732 from Patent EP1572962.
JD050287 - Sequence 31311 from Patent EP1572962.
JD563259 - Sequence 544283 from Patent EP1572962.
LF317253 - JP 2014500723-A/124756: Polycomb-Associated Non-Coding RNAs.
MA440750 - JP 2018138019-A/12676: Polycomb-Associated Non-Coding RNAs.
MA440751 - JP 2018138019-A/12677: Polycomb-Associated Non-Coding RNAs.
MA552832 - JP 2018138019-A/124758: Polycomb-Associated Non-Coding RNAs.
MA552831 - JP 2018138019-A/124757: Polycomb-Associated Non-Coding RNAs.
MA552830 - JP 2018138019-A/124756: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95816 (Reactome details) participates in the following event(s):

R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: BAG2_HUMAN, NM_004282, NP_004273, O95816, Q08AS9, Q6FID0
UCSC ID: uc003pdr.3
RefSeq Accession: NM_004282
Protein: O95816 (aka BAG2_HUMAN)
CCDS: CCDS4961.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004282.3
exon count: 3CDS single in 3' UTR: no RNA size: 2068
ORF size: 636CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1472.00frame shift in genome: no % Coverage: 99.23
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.