Description: Homo sapiens transducin (beta)-like 3 (TBL3), mRNA. RefSeq Summary (NM_006453): The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr16:2,022,064-2,028,751 Size: 6,688 Total Exon Count: 22 Strand: + Coding Region Position: hg19 chr16:2,022,166-2,028,686 Size: 6,521 Coding Exon Count: 22
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12788
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ898252 - Synthetic construct Homo sapiens clone ccsbBroadEn_07646 TBL3 gene, encodes complete protein. AK095076 - Homo sapiens cDNA FLJ37757 fis, clone BRHIP2023860, highly similar to WD-REPEAT PROTEIN SAZD. BC010231 - Homo sapiens transducin (beta)-like 3, mRNA (cDNA clone MGC:17508 IMAGE:3455740), complete cds. BC021563 - Homo sapiens transducin (beta)-like 3, mRNA (cDNA clone IMAGE:4811252), with apparent retained intron. BC014007 - Homo sapiens transducin (beta)-like 3, mRNA (cDNA clone MGC:20031 IMAGE:4040312), complete cds. AB209173 - Homo sapiens mRNA for transducin beta-like 3 variant protein. BC035409 - Homo sapiens transducin (beta)-like 3, mRNA (cDNA clone MGC:35053 IMAGE:5165833), complete cds. U02609 - Human transducin-like protein mRNA, complete cds. JD443995 - Sequence 425019 from Patent EP1572962. JD407326 - Sequence 388350 from Patent EP1572962. CU679657 - Synthetic construct Homo sapiens gateway clone IMAGE:100020455 5' read TBL3 mRNA. CU680738 - Synthetic construct Homo sapiens gateway clone IMAGE:100023488 5' read TBL3 mRNA. CU690084 - Synthetic construct Homo sapiens gateway clone IMAGE:100023264 5' read TBL3 mRNA. AB384871 - Synthetic construct DNA, clone: pF1KB3889, Homo sapiens TBL3 gene for WD repeat protein SAZD, complete cds, without stop codon, in Flexi system. BC002361 - Homo sapiens cDNA clone IMAGE:2961321, containing frame-shift errors. BC007620 - Homo sapiens transducin (beta)-like 3, mRNA (cDNA clone IMAGE:3355545), partial cds. JD157435 - Sequence 138459 from Patent EP1572962. JD126406 - Sequence 107430 from Patent EP1572962. JD251472 - Sequence 232496 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q12788 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA