Human Gene RNF214 (uc001pqt.4)
  Description: Homo sapiens ring finger protein 214 (RNF214), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:117,103,341-117,156,404 Size: 53,064 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr11:117,104,989-117,155,867 Size: 50,879 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:117,103,341-117,156,404)mRNA (may differ from genome)Protein (703 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RN214_HUMAN
DESCRIPTION: RecName: Full=RING finger protein 214;
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.47 RPKM in Testis
Total median expression: 374.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.30108-0.419 Picture PostScript Text
3' UTR -134.07537-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q8ND24
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  LF208467 - JP 2014500723-A/15970: Polycomb-Associated Non-Coding RNAs.
AK298923 - Homo sapiens cDNA FLJ54868 complete cds, weakly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-).
BC064581 - Homo sapiens cDNA clone IMAGE:5742803, containing frame-shift errors.
AK300160 - Homo sapiens cDNA FLJ58281 complete cds.
BC146891 - Homo sapiens ring finger protein 214, mRNA (cDNA clone MGC:181994 IMAGE:9056819), complete cds.
BC146901 - Homo sapiens ring finger protein 214, mRNA (cDNA clone MGC:182004 IMAGE:9056829), complete cds.
KJ904087 - Synthetic construct Homo sapiens clone ccsbBroadEn_13481 RNF214 gene, encodes complete protein.
JD149843 - Sequence 130867 from Patent EP1572962.
JD338645 - Sequence 319669 from Patent EP1572962.
BC031347 - Homo sapiens ring finger protein 214, mRNA (cDNA clone IMAGE:4895319).
AL834448 - Homo sapiens mRNA; cDNA DKFZp547C195 (from clone DKFZp547C195).
JD203398 - Sequence 184422 from Patent EP1572962.
JD350512 - Sequence 331536 from Patent EP1572962.
JD509790 - Sequence 490814 from Patent EP1572962.
JD090681 - Sequence 71705 from Patent EP1572962.
JD324014 - Sequence 305038 from Patent EP1572962.
JD509973 - Sequence 490997 from Patent EP1572962.
JD534185 - Sequence 515209 from Patent EP1572962.
JD267253 - Sequence 248277 from Patent EP1572962.
JD510365 - Sequence 491389 from Patent EP1572962.
JD046731 - Sequence 27755 from Patent EP1572962.
JD303765 - Sequence 284789 from Patent EP1572962.
JD040802 - Sequence 21826 from Patent EP1572962.
JD044885 - Sequence 25909 from Patent EP1572962.
JD271403 - Sequence 252427 from Patent EP1572962.
JD382806 - Sequence 363830 from Patent EP1572962.
MA444044 - JP 2018138019-A/15970: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RUW0, NM_207343, NP_997226, Q8ND24, RN214_HUMAN, uc001pqt.3
UCSC ID: uc001pqt.4
RefSeq Accession: NM_207343
Protein: Q8ND24 (aka RN214_HUMAN)
CCDS: CCDS41720.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_207343.3
exon count: 15CDS single in 3' UTR: no RNA size: 2770
ORF size: 2112CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4397.00frame shift in genome: no % Coverage: 99.53
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.