Human Gene ZDHHC16 (uc001knk.3)
  Description: Homo sapiens zinc finger, DHHC-type containing 16 (ZDHHC16), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:99,205,930-99,217,127 Size: 11,198 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr10:99,211,433-99,216,648 Size: 5,216 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:99,205,930-99,217,127)mRNA (may differ from genome)Protein (377 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZDH16_HUMAN
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC16; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 16; Short=DHHC-16;
FUNCTION: May be involved in apoptosis regulation (By similarity).
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBUNIT: Interacts with ABL1 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZDHHC16
CDC HuGE Published Literature: ZDHHC16

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.20 RPKM in Testis
Total median expression: 407.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.20186-0.490 Picture PostScript Text
3' UTR -143.53479-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q969W1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   FlyBase  
   Protein Sequence  
   Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0001654 eye development
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007507 heart development
GO:0018345 protein palmitoylation
GO:0021537 telencephalon development

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC008074 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone MGC:2911 IMAGE:3029918), complete cds.
BC012830 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone MGC:4571 IMAGE:3029918), complete cds.
AK297962 - Homo sapiens cDNA FLJ58319 complete cds, highly similar to Probable palmitoyltransferase ZDHHC16 (EC 2.3.1.-).
AK074427 - Homo sapiens cDNA FLJ23847 fis, clone KAT10287, highly similar to Mus musculus Abl-philin 2 mRNA.
BC011749 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone MGC:19657 IMAGE:3140177), complete cds.
BC050652 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone IMAGE:5241351), with apparent retained intron.
AF258563 - Homo sapiens PP3774 mRNA, complete cds.
BC033157 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone MGC:45785 IMAGE:4309312), complete cds.
BC004535 - Homo sapiens zinc finger, DHHC-type containing 16, mRNA (cDNA clone MGC:2993 IMAGE:3160750), complete cds.
AY359080 - Homo sapiens clone DNA108688 ZDHHC16 (UNQ2570) mRNA, complete cds.
JD406007 - Sequence 387031 from Patent EP1572962.
JD458155 - Sequence 439179 from Patent EP1572962.
JD128201 - Sequence 109225 from Patent EP1572962.
AJ294945 - Homo sapiens mRNA for hypothetical protein.
AB209272 - Homo sapiens mRNA for Abl-philin 2 isoform 3 variant protein.
AB464420 - Synthetic construct DNA, clone: pF1KB8158, Homo sapiens ZDHHC16 gene for zinc finger, DHHC-type containing protein 16, without stop codon, in Flexi system.
CU675921 - Synthetic construct Homo sapiens gateway clone IMAGE:100019148 5' read ZDHHC16 mRNA.
CU678754 - Synthetic construct Homo sapiens gateway clone IMAGE:100016994 5' read ZDHHC16 mRNA.
HQ447851 - Synthetic construct Homo sapiens clone IMAGE:100071195; CCSB004483_01 zinc finger, DHHC-type containing 16 (ZDHHC16) gene, encodes complete protein.
KJ894964 - Synthetic construct Homo sapiens clone ccsbBroadEn_04358 ZDHHC16 gene, encodes complete protein.
KJ899782 - Synthetic construct Homo sapiens clone ccsbBroadEn_09176 ZDHHC16 gene, encodes complete protein.
JD138501 - Sequence 119525 from Patent EP1572962.
JD250462 - Sequence 231486 from Patent EP1572962.
JD261220 - Sequence 242244 from Patent EP1572962.
JD050071 - Sequence 31095 from Patent EP1572962.
JD328385 - Sequence 309409 from Patent EP1572962.
JD074795 - Sequence 55819 from Patent EP1572962.
JD197014 - Sequence 178038 from Patent EP1572962.
JD203382 - Sequence 184406 from Patent EP1572962.
JD420567 - Sequence 401591 from Patent EP1572962.
JD326683 - Sequence 307707 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DR52, D3DR53, D3DR54, NM_032327, NP_932163, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3, UNQ2570/PRO6258, ZDH16_HUMAN
UCSC ID: uc001knk.3
RefSeq Accession: NM_032327
Protein: Q969W1 (aka ZDH16_HUMAN or ZDHG_HUMAN)
CCDS: CCDS7460.1, CCDS7461.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032327.2
exon count: 11CDS single in 3' UTR: no RNA size: 1816
ORF size: 1134CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2356.00frame shift in genome: no % Coverage: 99.06
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.