Description: Homo sapiens dedicator of cytokinesis 2 (DOCK2), mRNA. RefSeq Summary (NM_004946): The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]. Transcript (Including UTRs) Position: hg19 chr5:169,064,251-169,510,386 Size: 446,136 Total Exon Count: 52 Strand: + Coding Region Position: hg19 chr5:169,064,331-169,509,862 Size: 445,532 Coding Exon Count: 52
ID:DOCK2_HUMAN DESCRIPTION: RecName: Full=Dedicator of cytokinesis protein 2; FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. SUBUNIT: Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z. SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin. TISSUE SPECIFICITY: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. DOMAIN: The DHR-2 domain may mediate the GEF activity (By similarity). SIMILARITY: Belongs to the DOCK family. SIMILARITY: Contains 1 DHR-1 domain. SIMILARITY: Contains 1 DHR-2 domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAA13200.1; Type=Erroneous initiation;
Asthma C Ober et al. American journal of human genetics 2000, A second-generation genomewide screen for asthma-susceptibility alleles in a founder population., American journal of human genetics.
[PubMed 11022011]
Asthma C Ober et al. American journal of human genetics 2000, A second-generation genomewide screen for asthma-susceptibility alleles in a founder population., American journal of human genetics.
[PubMed 11022011]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92608
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D86964 - Homo sapiens mRNA for KIAA0209 gene. BC104900 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone MGC:132560 IMAGE:8143903), complete cds. BC113457 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone MGC:142017 IMAGE:8322509), complete cds. BC143358 - Homo sapiens cDNA clone IMAGE:9051863. AB463008 - Synthetic construct DNA, clone: pF1KA0209, Homo sapiens DOCK2 gene for dedicator of cytokinesis 2, without stop codon, in Flexi system. BC016996 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:4413481), complete cds. AK128107 - Homo sapiens cDNA FLJ46228 fis, clone TESTI4014908, highly similar to Dedicator of cytokinesis protein 2. BC035613 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:4385164), partial cds. BC084556 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:5933446), partial cds. JD216123 - Sequence 197147 from Patent EP1572962. AK128449 - Homo sapiens cDNA FLJ46592 fis, clone THYMU3045510, highly similar to Dedicator of cytokinesis protein 2. AK130744 - Homo sapiens cDNA FLJ27234 fis, clone SYN07051. JD323286 - Sequence 304310 from Patent EP1572962. JD427461 - Sequence 408485 from Patent EP1572962. JD479699 - Sequence 460723 from Patent EP1572962. JD456118 - Sequence 437142 from Patent EP1572962. JD376416 - Sequence 357440 from Patent EP1572962. JD503341 - Sequence 484365 from Patent EP1572962. JD242413 - Sequence 223437 from Patent EP1572962. JD284821 - Sequence 265845 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04062 - Chemokine signaling pathway hsa04666 - Fc gamma R-mediated phagocytosis
Reactome (by CSHL, EBI, and GO)
Protein Q92608 (Reactome details) participates in the following event(s):
R-HSA-200952 Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction R-HSA-1011598 DOCKs bind to RhoGEFs R-HSA-6798749 Exocytosis of specific granule lumen proteins R-HSA-164944 Nef and signal transduction R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-6798695 Neutrophil degranulation R-HSA-109582 Hemostasis R-HSA-162909 Host Interactions of HIV factors R-HSA-168249 Innate Immune System R-HSA-162906 HIV Infection R-HSA-168256 Immune System R-HSA-5663205 Infectious disease R-HSA-1643685 Disease