Description: Homo sapiens NME/NM23 nucleoside diphosphate kinase 6 (NME6), mRNA. RefSeq Summary (NM_005793): Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr3:48,335,589-48,342,848 Size: 7,260 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr3:48,336,127-48,342,802 Size: 6,676 Coding Exon Count: 6
ID:NDK6_HUMAN DESCRIPTION: RecName: Full=Nucleoside diphosphate kinase 6; Short=NDK 6; Short=NDP kinase 6; EC=2.7.4.6; AltName: Full=Inhibitor of p53-induced apoptosis-alpha; Short=IPIA-alpha; AltName: Full=nm23-H6; FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis. CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. COFACTOR: Magnesium (By similarity). TISSUE SPECIFICITY: Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen. SIMILARITY: Belongs to the NDK family. SEQUENCE CAUTION: Sequence=AAC69439.1; Type=Erroneous initiation; Sequence=AAH01808.1; Type=Erroneous initiation; Sequence=AAH12828.1; Type=Erroneous initiation; Sequence=BAD96275.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75414
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF051941 - Homo sapiens type 6 nucleoside diphosphate kinase NM23-H6 (NM23-H6) mRNA, complete cds. BC001808 - Homo sapiens non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase), mRNA (cDNA clone MGC:1889 IMAGE:2966629), complete cds. BC012828 - Homo sapiens non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase), mRNA (cDNA clone MGC:4514 IMAGE:2966629), complete cds. AK308970 - Homo sapiens cDNA, FLJ99011. AK222555 - Homo sapiens mRNA for nucleoside diphosphate kinase type 6 variant, clone: CAE02417. AK297364 - Homo sapiens cDNA FLJ50578 complete cds, moderately similar to Nucleoside diphosphate kinase 6 (EC 2.7.4.6). AK294809 - Homo sapiens cDNA FLJ50505 complete cds, moderately similar to Nucleoside diphosphate kinase 6 (EC 2.7.4.6). U90449 - Human inhibitor of p53-induced apoptosis-alpha (IPIA-alpha) mRNA, complete cds. JD329276 - Sequence 310300 from Patent EP1572962. JD168797 - Sequence 149821 from Patent EP1572962. KJ892956 - Synthetic construct Homo sapiens clone ccsbBroadEn_02350 NME6 gene, encodes complete protein. KJ905388 - Synthetic construct Homo sapiens clone ccsbBroadEn_14957 NME6 gene, encodes complete protein. DQ892283 - Synthetic construct clone IMAGE:100004913; FLH184842.01X; RZPDo839C06146D non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (NME6) gene, encodes complete protein. DQ895483 - Synthetic construct Homo sapiens clone IMAGE:100009943; FLH184838.01L; RZPDo839C06145D non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (NME6) gene, encodes complete protein. AK311152 - Homo sapiens cDNA, FLJ18194. AK307332 - Homo sapiens cDNA, FLJ97280. AK309090 - Homo sapiens cDNA, FLJ99131.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00230 - Purine metabolism hsa00240 - Pyrimidine metabolism hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY-5687 - pyrimidine ribonucleotides interconversion PWY-6126 - adenosine nucleotides de novo biosynthesis PWY0-162 - pyrimidine ribonucleotides de novo biosynthesis PWY0-163 - salvage pathways of pyrimidine ribonucleotides PWY0-166 - pyrimidine deoxyribonucleotides de novo biosynthesis I
Reactome (by CSHL, EBI, and GO)
Protein O75414 (Reactome details) participates in the following event(s):
US Server
