Human Gene PRSS48 (uc011cif.2)
Description: Homo sapiens protease, serine, 48 (PRSS48), mRNA.Transcript (Including UTRs) Position: hg19 chr4:152,198,325-152,212,605 Size: 14,281 Total Exon Count: 5 Strand: +Coding Region Position: hg19 chr4:152,198,325-152,212,605 Size: 14,281 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PRS48_HUMAN DESCRIPTION: RecName: Full=Serine protease 48; EC=3.4.21.-; AltName: Full=Epidermis-specific serine protease-like protein; Flags: Precursor;SUBCELLULAR LOCATION: Secreted (Potential).SIMILARITY: Belongs to the peptidase S1 family.SIMILARITY: Contains 1 peptidase S1 domain.SEQUENCE CAUTION: Sequence=CAD67963.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009003 - Pept_cys/ser_Trypsin-likeIPR018114 - Peptidase_S1/S6_ASIPR001254 - Peptidase_S1_S6IPR001314 - Peptidase_S1APfam Domains: PF00089 - TrypsinPF09342 - Domain of unknown function (DUF1986)SCOP Domains: 50494 - Trypsin-like serine proteasesModBase Predicted Comparative 3D Structure on Q7RTY5 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog Gene Details Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ900655 - Synthetic construct Homo sapiens clone ccsbBroadEn_10049 PRSS48 gene, encodes complete protein.BC121109 - Homo sapiens epidermis-specific serine protease-like protein, mRNA (cDNA clone MGC:150407 IMAGE:40120369), complete cds.BC121110 - Homo sapiens epidermis-specific serine protease-like protein, mRNA (cDNA clone MGC:150408 IMAGE:40120371), complete cds.HM005378 - Homo sapiens clone HTL-T-65 testicular tissue protein Li 65 mRNA, complete cds.
Other Names for This Gene
Alternate Gene Symbols: ESSPL, NM_183375, NP_899231, PRS48_HUMAN, Q08E82, Q0VAD4, Q7RTY5UCSC ID: uc011cif.2RefSeq Accession: NM_183375 Protein: Q7RTY5
(aka PRS48_HUMAN)CCDS: CCDS47145.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_183375.2
exon count:
5 CDS single in 3' UTR:
no
RNA size:
987 ORF size:
987 CDS single in intron:
no
Alignment % ID:
100.00 txCdsPredict score:
2174.00 frame shift in genome:
no
% Coverage:
100.00 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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US Server
