Human Gene LINS1 (uc002bwg.3)
  Description: Homo sapiens lines homolog (Drosophila) (LINS1), transcript variant 6, mRNA.
RefSeq Summary (NM_001040616): The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017].
Transcript (Including UTRs)
   Position: hg19 chr15:101,109,428-101,142,445 Size: 33,018 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr15:101,109,443-101,121,047 Size: 11,605 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:101,109,428-101,142,445)mRNA (may differ from genome)Protein (757 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HPRDLynxMalacardsMGIneXtProtOMIM
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LINES_HUMAN
DESCRIPTION: RecName: Full=Protein Lines homolog; AltName: Full=Protein Lines homolog 1; AltName: Full=Wnt-signaling molecule Lines homolog 1;
TISSUE SPECIFICITY: Expressed in adult testis, prostate, prostate, spleen, thymus, skeletal muscle, fetal kidney and brain.
SIMILARITY: Belongs to the protein lines family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): LINS1
CDC HuGE Published Literature: LINS1

-  MalaCards Disease Associations
  MalaCards Gene Search: LINS1
Diseases sorted by gene-association score: mental retardation, autosomal recessive 27* (1029), autosomal recessive non-syndromic intellectual disability* (73), non-syndromic intellectual disability (13), ebola hemorrhagic fever (6), mutism (5), syndromic intellectual disability (4)
* = Manually curated disease association

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.54 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 96.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.60223-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024875 - Protein_Lines

Pfam Domains:
PF14694 - Lines N-terminus
PF14695 - Lines C-terminus

ModBase Predicted Comparative 3D Structure on Q8NG48
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   FlyBase  
   Protein Sequence  
   Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0050890 cognition


-  Descriptions from all associated GenBank mRNAs
  AB083157 - Homo sapiens mRNA for WINS1 protein with Drosophila Lines (Lin) homologous domain, complete cds.
AK095448 - Homo sapiens cDNA FLJ38129 fis, clone D6OST2000445.
AK093868 - Homo sapiens cDNA FLJ36549 fis, clone TRACH2008081.
AX748344 - Sequence 1869 from Patent EP1308459.
AK001445 - Homo sapiens cDNA FLJ10583 fis, clone NT2RP2003629.
AK292972 - Homo sapiens cDNA FLJ77217 complete cds, highly similar to Homo sapiens lines homolog 1 (Drosophila), transcript variant 2, mRNA.
AK298946 - Homo sapiens cDNA FLJ54130 complete cds, highly similar to Homo sapiens lines homolog 1 (LINS1), transcript variant 1, mRNA.
BC010363 - Homo sapiens lines homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:4133046), with apparent retained intron.
KJ902783 - Synthetic construct Homo sapiens clone ccsbBroadEn_12177 LINS gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: LINES_HUMAN, LINS, NM_001040616, NP_001035706, Q8NG48, Q96FW2, Q9NVQ3, WINS1
UCSC ID: uc002bwg.3
RefSeq Accession: NM_001040616
Protein: Q8NG48 (aka LINES_HUMAN)
CCDS: CCDS10385.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001040616.2
exon count: 7CDS single in 3' UTR: no RNA size: 2512
ORF size: 2274CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4647.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.