Human Gene PODN (uc010onr.2)
  Description: Homo sapiens podocan (PODN), transcript variant 2, mRNA.
RefSeq Summary (NM_001199081): The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016].
Transcript (Including UTRs)
   Position: hg19 chr1:53,527,724-53,551,174 Size: 23,451 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr1:53,532,508-53,547,833 Size: 15,326 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:53,527,724-53,551,174)mRNA (may differ from genome)Protein (642 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PODN
CDC HuGE Published Literature: PODN

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 101.30 RPKM in Nerve - Tibial
Total median expression: 1276.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.00281-0.416 Picture PostScript Text
3' UTR -366.701017-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00560 - Leucine Rich Repeat
PF13306 - Leucine rich repeats (6 copies)
PF13516 - Leucine Rich repeat
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q7Z5L7-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AY358294 - Homo sapiens clone DNA40982 EGEE293 (UNQ293) mRNA, complete cds.
AK314096 - Homo sapiens cDNA, FLJ94779.
AK300847 - Homo sapiens cDNA FLJ54652 complete cds, highly similar to Homo sapiens podocan (PODN), mRNA.
AY313607 - Homo sapiens podocan protein (PODN) mRNA, complete cds.
AK299375 - Homo sapiens cDNA FLJ50044 complete cds, highly similar to Homo sapiens podocan (PODN), mRNA.
AK304599 - Homo sapiens cDNA FLJ53893 complete cds, highly similar to Homo sapiens podocan (PODN), mRNA.
BC030608 - Homo sapiens podocan, mRNA (cDNA clone MGC:26993 IMAGE:4826932), complete cds.
AK296649 - Homo sapiens cDNA FLJ50092 complete cds, highly similar to Homo sapiens podocan (PODN), mRNA.
CU688942 - Synthetic construct Homo sapiens gateway clone IMAGE:100020950 5' read PODN mRNA.
KJ900113 - Synthetic construct Homo sapiens clone ccsbBroadEn_09507 PODN gene, encodes complete protein.
BC028292 - Homo sapiens podocan, mRNA (cDNA clone MGC:24995 IMAGE:4938380), complete cds.
JD191922 - Sequence 172946 from Patent EP1572962.
JD069416 - Sequence 50440 from Patent EP1572962.
JD151090 - Sequence 132114 from Patent EP1572962.
JD276993 - Sequence 258017 from Patent EP1572962.
JD496276 - Sequence 477300 from Patent EP1572962.
JD143840 - Sequence 124864 from Patent EP1572962.
JD222418 - Sequence 203442 from Patent EP1572962.
JD458725 - Sequence 439749 from Patent EP1572962.
AL122104 - Homo sapiens mRNA; cDNA DKFZp434A1627 (from clone DKFZp434A1627).
JD178259 - Sequence 159283 from Patent EP1572962.
JD524420 - Sequence 505444 from Patent EP1572962.
JD356029 - Sequence 337053 from Patent EP1572962.
DQ894955 - Synthetic construct Homo sapiens clone IMAGE:100009415; FLH179781.01L; RZPDo839C09131D podocan (PODN) gene, encodes complete protein.
KJ904978 - Synthetic construct Homo sapiens clone ccsbBroadEn_14372 PODN gene, encodes complete protein.
DQ891771 - Synthetic construct clone IMAGE:100004401; FLH179785.01X; RZPDo839C09132D podocan (PODN) gene, encodes complete protein.
JD471382 - Sequence 452406 from Patent EP1572962.
JD087786 - Sequence 68810 from Patent EP1572962.
JD123454 - Sequence 104478 from Patent EP1572962.
JD381478 - Sequence 362502 from Patent EP1572962.
JD412636 - Sequence 393660 from Patent EP1572962.
BC024024 - Homo sapiens cDNA clone IMAGE:4690090.
JD377378 - Sequence 358402 from Patent EP1572962.
JD110663 - Sequence 91687 from Patent EP1572962.
JD386502 - Sequence 367526 from Patent EP1572962.
JD189992 - Sequence 171016 from Patent EP1572962.
JD437642 - Sequence 418666 from Patent EP1572962.
JD097175 - Sequence 78199 from Patent EP1572962.
JD055443 - Sequence 36467 from Patent EP1572962.
JD360408 - Sequence 341432 from Patent EP1572962.
JD228836 - Sequence 209860 from Patent EP1572962.
JD097127 - Sequence 78151 from Patent EP1572962.
JD419713 - Sequence 400737 from Patent EP1572962.
JD174582 - Sequence 155606 from Patent EP1572962.
JD159501 - Sequence 140525 from Patent EP1572962.
JD453822 - Sequence 434846 from Patent EP1572962.
JD519669 - Sequence 500693 from Patent EP1572962.
JD057267 - Sequence 38291 from Patent EP1572962.
JD393154 - Sequence 374178 from Patent EP1572962.
JD185897 - Sequence 166921 from Patent EP1572962.
JD114496 - Sequence 95520 from Patent EP1572962.
JD310160 - Sequence 291184 from Patent EP1572962.
JD346893 - Sequence 327917 from Patent EP1572962.
JD465588 - Sequence 446612 from Patent EP1572962.
JD273029 - Sequence 254053 from Patent EP1572962.
JD078986 - Sequence 60010 from Patent EP1572962.
JD544201 - Sequence 525225 from Patent EP1572962.
JD485174 - Sequence 466198 from Patent EP1572962.
JD485286 - Sequence 466310 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001199081, NP_001186010, Q7Z5L7-2, SLRR5A, UNQ293/PRO332
UCSC ID: uc010onr.2
RefSeq Accession: NM_001199081
Protein: Q7Z5L7-2, splice isoform of Q7Z5L7 CCDS: CCDS55602.1, CCDS573.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199081.1
exon count: 12CDS single in 3' UTR: no RNA size: 3075
ORF size: 1929CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4283.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.