Description: Homo sapiens laminin, alpha 4 (LAMA4), transcript variant 1, mRNA. RefSeq Summary (NM_001105206): Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr6:112,429,134-112,575,917 Size: 146,784 Total Exon Count: 39 Strand: - Coding Region Position: hg19 chr6:112,430,640-112,575,352 Size: 144,713 Coding Exon Count: 38
ID:LAMA4_HUMAN DESCRIPTION: RecName: Full=Laminin subunit alpha-4; AltName: Full=Laminin-14 subunit alpha; AltName: Full=Laminin-8 subunit alpha; AltName: Full=Laminin-9 subunit alpha; Flags: Precursor; FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. TISSUE SPECIFICITY: In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis. DOMAIN: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. DOMAIN: Domain G is globular. SIMILARITY: Contains 4 laminin EGF-like domains. SIMILARITY: Contains 5 laminin G-like domains. CAUTION: Gene LAMA4 was formerly called LAMA3. SEQUENCE CAUTION: Sequence=BAE06109.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16363
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC066552 - Homo sapiens laminin, alpha 4, mRNA (cDNA clone MGC:74960 IMAGE:6164247), complete cds. S78569 - laminin alpha 4 chain [human, fetal lung, mRNA, 6204 nt]. X76939 - H.sapiens mRNA for laminin alpha4. X91171 - H.sapiens mRNA for laminin alpha 4 protein. AB210027 - Homo sapiens mRNA for LAMA4 variant protein, clone: hh01833. AB384677 - Synthetic construct DNA, clone: pF1KB0049, Homo sapiens LAMA4 gene for laminin subunit alpha-4 precursor, complete cds, without stop codon, in Flexi system. BX648467 - Homo sapiens mRNA; cDNA DKFZp686D23145 (from clone DKFZp686D23145). AK304401 - Homo sapiens cDNA FLJ61727 partial cds, highly similar to Laminin alpha-4 chain precursor. JD507000 - Sequence 488024 from Patent EP1572962. JD379791 - Sequence 360815 from Patent EP1572962. JD274339 - Sequence 255363 from Patent EP1572962. JD108368 - Sequence 89392 from Patent EP1572962. X70904 - H.sapiens LAMA3 mRNA for laminin Ah. JD118274 - Sequence 99298 from Patent EP1572962. JD563401 - Sequence 544425 from Patent EP1572962. AK027151 - Homo sapiens cDNA: FLJ23498 fis, clone LNG02683. BC026237 - Homo sapiens laminin, alpha 4, mRNA (cDNA clone IMAGE:4702204), partial cds. U77706 - Human laminin alpha 4 chain (LAMA4*-1) mRNA, complete cds. CR407622 - Homo sapiens full open reading frame cDNA clone RZPDo834C052D for gene LAMA4, laminin, alpha 4 complete cds, without stopcodon. LF212334 - JP 2014500723-A/19837: Polycomb-Associated Non-Coding RNAs. BC004241 - Homo sapiens laminin, alpha 4, mRNA (cDNA clone IMAGE:3623597), complete cds. BT006690 - Homo sapiens laminin, alpha 4 mRNA, complete cds. JF432726 - Synthetic construct Homo sapiens clone IMAGE:100073969 laminin, alpha 4 (LAMA4) gene, encodes complete protein. KJ891532 - Synthetic construct Homo sapiens clone ccsbBroadEn_00926 LAMA4 gene, encodes complete protein. LF208734 - JP 2014500723-A/16237: Polycomb-Associated Non-Coding RNAs. JD097753 - Sequence 78777 from Patent EP1572962. JD404414 - Sequence 385438 from Patent EP1572962. JD495726 - Sequence 476750 from Patent EP1572962. LF322168 - JP 2014500723-A/129671: Polycomb-Associated Non-Coding RNAs. MA557745 - JP 2018138019-A/129671: Polycomb-Associated Non-Coding RNAs. MA447911 - JP 2018138019-A/19837: Polycomb-Associated Non-Coding RNAs. MA444311 - JP 2018138019-A/16237: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04510 - Focal adhesion hsa04512 - ECM-receptor interaction hsa05200 - Pathways in cancer hsa05222 - Small cell lung cancer
BioCarta from NCI Cancer Genome Anatomy Project h_agrPathway - Agrin in Postsynaptic Differentiation
Reactome (by CSHL, EBI, and GO)
Protein Q16363 (Reactome details) participates in the following event(s):
US Server
