Description: Homo sapiens cornichon homolog 2 (Drosophila) (CNIH2), transcript variant 1, mRNA. RefSeq Summary (NM_182553): The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr11:66,045,672-66,051,685 Size: 6,014 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr11:66,045,928-66,051,068 Size: 5,141 Coding Exon Count: 6
ID:CNIH2_HUMAN DESCRIPTION: RecName: Full=Protein cornichon homolog 2; AltName: Full=Cornichon-like protein; FUNCTION: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. SUBUNIT: Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with CACGN8 (By similarity). Interacts with GRIA1. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells) (By similarity). SIMILARITY: Belongs to the cornichon family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PI25
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0016192 vesicle-mediated transport GO:0035249 synaptic transmission, glutamatergic GO:0042391 regulation of membrane potential GO:0048208 COPII vesicle coating GO:0051668 localization within membrane GO:1902684 negative regulation of receptor localization to synapse GO:1903743 negative regulation of anterograde synaptic vesicle transport GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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