Description: Homo sapiens polymerase (RNA) II (DNA directed) polypeptide J3 (POLR2J3), mRNA. RefSeq Summary (NM_001097615): This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr7:102,178,366-102,213,068 Size: 34,703 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr7:102,207,498-102,212,968 Size: 5,471 Coding Exon Count: 4
ID:RPB1B_HUMAN DESCRIPTION: RecName: Full=DNA-directed RNA polymerase II subunit RPB11-b1; Short=RNA polymerase II subunit B11-b1; Short=RPB11b1; AltName: Full=DNA-directed RNA polymerase II subunit J2; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 55257 - RBP11-like subunits of RNA polymerase
ModBase Predicted Comparative 3D Structure on Q9GZM3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
