Human Gene URB2 (uc001hts.1)
  Description: Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (URB2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:229,761,981-229,795,946 Size: 33,966 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr1:229,763,381-229,795,044 Size: 31,664 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:229,761,981-229,795,946)mRNA (may differ from genome)Protein (1524 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: URB2_HUMAN
DESCRIPTION: RecName: Full=Unhealthy ribosome biogenesis protein 2 homolog;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SEQUENCE CAUTION: Sequence=BAA09482.3; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: URB2
Diseases sorted by gene-association score: buruli ulcer (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.48 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 83.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.30136-0.414 Picture PostScript Text
3' UTR -246.92902-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018849 - Urb2/Npa2_C

Pfam Domains:
PF10441 - Urb2/Npa2 family

ModBase Predicted Comparative 3D Structure on Q14146
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016235 aggresome
GO:0030496 midbody


-  Descriptions from all associated GenBank mRNAs
  AK291013 - Homo sapiens cDNA FLJ75337 complete cds.
D50923 - Homo sapiens KIAA0133 mRNA.
BC059381 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:30337179), partial cds.
BC114559 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:138837 IMAGE:40082897), complete cds.
BC114963 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:138838 IMAGE:40082900), complete cds.
AB463082 - Synthetic construct DNA, clone: pF1KA0133, Homo sapiens KIAA0133 gene, without stop codon, in Flexi system.
KJ892856 - Synthetic construct Homo sapiens clone ccsbBroadEn_02250 URB2 gene, encodes complete protein.
JD129126 - Sequence 110150 from Patent EP1572962.
JD406140 - Sequence 387164 from Patent EP1572962.
JD368174 - Sequence 349198 from Patent EP1572962.
JD080509 - Sequence 61533 from Patent EP1572962.
JD318559 - Sequence 299583 from Patent EP1572962.
JD269949 - Sequence 250973 from Patent EP1572962.
JD218079 - Sequence 199103 from Patent EP1572962.
JD422818 - Sequence 403842 from Patent EP1572962.
JD324675 - Sequence 305699 from Patent EP1572962.
JD286106 - Sequence 267130 from Patent EP1572962.
JD324028 - Sequence 305052 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0133, NM_014777, NP_055592, Q14146, Q5VYC9, URB2_HUMAN
UCSC ID: uc001hts.1
RefSeq Accession: NM_014777
Protein: Q14146 (aka URB2_HUMAN)
CCDS: CCDS31052.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014777.2
exon count: 10CDS single in 3' UTR: no RNA size: 5613
ORF size: 4575CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 9350.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.