Human Gene URB2 (uc001hts.1)
Description: Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (URB2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:229,761,981-229,795,946 Size: 33,966 Total Exon Count: 10 Strand: +
Coding Region
Position: hg19 chr1:229,763,381-229,795,044 Size: 31,664 Coding Exon Count: 9
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: URB2_HUMAN
DESCRIPTION: RecName: Full=Unhealthy ribosome biogenesis protein 2 homolog;
SUBCELLULAR LOCATION: Nucleus, nucleolus.SEQUENCE CAUTION: Sequence=BAA09482.3; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: URB2
Diseases sorted by gene-association score: buruli ulcer (7)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR018849 - Urb2/Npa2_C
Pfam Domains: PF10441 - Urb2/Npa2 family
ModBase Predicted Comparative 3D Structure on Q14146
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK291013 - Homo sapiens cDNA FLJ75337 complete cds.D50923 - Homo sapiens KIAA0133 mRNA.BC059381 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:30337179), partial cds.BC114559 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:138837 IMAGE:40082897), complete cds.BC114963 - Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:138838 IMAGE:40082900), complete cds.AB463082 - Synthetic construct DNA, clone: pF1KA0133, Homo sapiens KIAA0133 gene, without stop codon, in Flexi system.KJ892856 - Synthetic construct Homo sapiens clone ccsbBroadEn_02250 URB2 gene, encodes complete protein.JD129126 - Sequence 110150 from Patent EP1572962.JD406140 - Sequence 387164 from Patent EP1572962.JD368174 - Sequence 349198 from Patent EP1572962.JD080509 - Sequence 61533 from Patent EP1572962.JD318559 - Sequence 299583 from Patent EP1572962.JD269949 - Sequence 250973 from Patent EP1572962.JD218079 - Sequence 199103 from Patent EP1572962.JD422818 - Sequence 403842 from Patent EP1572962.JD324675 - Sequence 305699 from Patent EP1572962.JD286106 - Sequence 267130 from Patent EP1572962.JD324028 - Sequence 305052 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: KIAA0133, NM_014777, NP_055592, Q14146, Q5VYC9, URB2_HUMANUCSC ID: uc001hts.1RefSeq Accession: NM_014777
Protein: Q14146
(aka URB2_HUMAN)
CCDS: CCDS31052.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_014777.2
exon count:
10 CDS single in 3' UTR:
no
RNA size:
5613
ORF size:
4575 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
9350.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.