Description: Homo sapiens golgin A1 (GOLGA1), mRNA. RefSeq Summary (NM_002077): The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]. Transcript (Including UTRs) Position: hg19 chr9:127,640,573-127,703,386 Size: 62,814 Total Exon Count: 23 Strand: - Coding Region Position: hg19 chr9:127,642,809-127,700,990 Size: 58,182 Coding Exon Count: 21
ID:GOGA1_HUMAN DESCRIPTION: RecName: Full=Golgin subfamily A member 1; AltName: Full=Golgin-97; FUNCTION: Probably involved in maintaining Golgi structure. SUBUNIT: Binds RAB6A. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. DOMAIN: Extended rod-like protein with coiled-coil domains. MISCELLANEOUS: Antibodies against GOLGA1 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex. SIMILARITY: Contains 1 GRIP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92805
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC032853 - Homo sapiens golgi autoantigen, golgin subfamily a, 1, mRNA (cDNA clone MGC:33154 IMAGE:4828793), complete cds. U51587 - Homo sapiens Golgi complex autoantigen golgin-97 mRNA, complete cds. AB208858 - Homo sapiens mRNA for golgin 97 variant protein. AK302445 - Homo sapiens cDNA FLJ51573 complete cds, highly similar to Golgin subfamily A member 1. DQ892461 - Synthetic construct clone IMAGE:100005091; FLH186537.01X; RZPDo839F0771D golgi autoantigen, golgin subfamily a, 1 (GOLGA1) gene, encodes complete protein. AB590437 - Synthetic construct DNA, clone: pFN21AE1500, Homo sapiens GOLGA1 gene for golgi autoantigen, golgin subfamily a, 1, without stop codon, in Flexi system. KJ896906 - Synthetic construct Homo sapiens clone ccsbBroadEn_06300 GOLGA1 gene, encodes complete protein. JD566909 - Sequence 547933 from Patent EP1572962. JD173890 - Sequence 154914 from Patent EP1572962. JD280692 - Sequence 261716 from Patent EP1572962. JD325159 - Sequence 306183 from Patent EP1572962. JD060834 - Sequence 41858 from Patent EP1572962. JD370968 - Sequence 351992 from Patent EP1572962. JD171679 - Sequence 152703 from Patent EP1572962. JD173803 - Sequence 154827 from Patent EP1572962. JD463535 - Sequence 444559 from Patent EP1572962. JD252410 - Sequence 233434 from Patent EP1572962. JD315562 - Sequence 296586 from Patent EP1572962. JD306692 - Sequence 287716 from Patent EP1572962. JD045285 - Sequence 26309 from Patent EP1572962. JD345029 - Sequence 326053 from Patent EP1572962. JD117782 - Sequence 98806 from Patent EP1572962. JD405595 - Sequence 386619 from Patent EP1572962. JD461475 - Sequence 442499 from Patent EP1572962. JD387853 - Sequence 368877 from Patent EP1572962. JD050988 - Sequence 32012 from Patent EP1572962. JD296168 - Sequence 277192 from Patent EP1572962. JD475388 - Sequence 456412 from Patent EP1572962. JD358572 - Sequence 339596 from Patent EP1572962. JD274975 - Sequence 255999 from Patent EP1572962. JD271666 - Sequence 252690 from Patent EP1572962. JD151721 - Sequence 132745 from Patent EP1572962. JD506648 - Sequence 487672 from Patent EP1572962. JD284534 - Sequence 265558 from Patent EP1572962. JD086188 - Sequence 67212 from Patent EP1572962. JD266965 - Sequence 247989 from Patent EP1572962. JD036816 - Sequence 17840 from Patent EP1572962. JD117595 - Sequence 98619 from Patent EP1572962. JD098789 - Sequence 79813 from Patent EP1572962. JD516282 - Sequence 497306 from Patent EP1572962. JD158537 - Sequence 139561 from Patent EP1572962. AK307789 - Homo sapiens cDNA, FLJ97737. JD229596 - Sequence 210620 from Patent EP1572962. JD161939 - Sequence 142963 from Patent EP1572962. JD218731 - Sequence 199755 from Patent EP1572962. JD459012 - Sequence 440036 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92805 (Reactome details) participates in the following event(s):
R-HSA-6814091 ARL1 recruits TGN Golgin homodimers R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport