Human Gene NXPE1 (uc001ppa.3)
  Description: Homo sapiens neurexophilin and PC-esterase domain family, member 1 (NXPE1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:114,392,437-114,430,580 Size: 38,144 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr11:114,392,690-114,401,303 Size: 8,614 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:114,392,437-114,430,580)mRNA (may differ from genome)Protein (405 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NXPE1_HUMAN
DESCRIPTION: RecName: Full=NXPE family member 1; AltName: Full=Protein FAM55A; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the NXPE family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.01 RPKM in Colon - Transverse
Total median expression: 33.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -105.95417-0.254 Picture PostScript Text
3' UTR -41.13253-0.163 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014756 - Ig_E-set
IPR026057 - PC-Esterase

Pfam Domains:
PF06312 - Neurexophilin

ModBase Predicted Comparative 3D Structure on Q8N323
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC029049 - Homo sapiens family with sequence similarity 55, member A, mRNA (cDNA clone MGC:34290 IMAGE:5186472), complete cds.
BX648601 - Homo sapiens mRNA; cDNA DKFZp686C13213 (from clone DKFZp686C13213).
JD437487 - Sequence 418511 from Patent EP1572962.
JD250699 - Sequence 231723 from Patent EP1572962.
DQ890854 - Synthetic construct clone IMAGE:100003484; FLH166496.01X; RZPDo839H0686D family with sequence similarity 55, member A (FAM55A) gene, encodes complete protein.
KJ900071 - Synthetic construct Homo sapiens clone ccsbBroadEn_09465 FAM55A gene, encodes complete protein.
DQ894008 - Synthetic construct Homo sapiens clone IMAGE:100008468; FLH166492.01L; RZPDo839H0685D family with sequence similarity 55, member A (FAM55A) gene, encodes complete protein.
CU688590 - Synthetic construct Homo sapiens gateway clone IMAGE:100019257 5' read FAM55A mRNA.
BC037844 - Homo sapiens family with sequence similarity 55, member A, mRNA (cDNA clone IMAGE:4814877).
JD243950 - Sequence 224974 from Patent EP1572962.
JD214905 - Sequence 195929 from Patent EP1572962.
JD221609 - Sequence 202633 from Patent EP1572962.
JD097254 - Sequence 78278 from Patent EP1572962.
JD097159 - Sequence 78183 from Patent EP1572962.
JD119800 - Sequence 100824 from Patent EP1572962.
JD365527 - Sequence 346551 from Patent EP1572962.
JD040420 - Sequence 21444 from Patent EP1572962.
JD324201 - Sequence 305225 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B0YJ13, FAM55A, NM_152315, NP_689528, NXPE1_HUMAN, Q8N323
UCSC ID: uc001ppa.3
RefSeq Accession: NM_152315
Protein: Q8N323 (aka NXPE1_HUMAN)
CCDS: CCDS8372.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152315.2
exon count: 6CDS single in 3' UTR: no RNA size: 1953
ORF size: 1218CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2615.00frame shift in genome: no % Coverage: 96.67
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.