Human Gene EDRF1 (uc001liq.1)
  Description: Homo sapiens chromosome 10 open reading frame 137 (EDRF1), transcript variant 1, mRNA.
RefSeq Summary (NM_001202438): This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Transcript (Including UTRs)
   Position: hg19 chr10:127,408,084-127,452,712 Size: 44,629 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg19 chr10:127,408,377-127,452,041 Size: 43,665 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:127,408,084-127,452,712)mRNA (may differ from genome)Protein (1238 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHPRDLynxMalacardsMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EDRF1_HUMAN
DESCRIPTION: RecName: Full=Erythroid differentiation-related factor 1;
FUNCTION: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Contains 2 TPR repeats.
SEQUENCE CAUTION: Sequence=BAG37462.1; Type=Erroneous initiation; Sequence=CAH73214.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EDRF1
Diseases sorted by gene-association score: spherocytosis, type 2 (7)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.74 RPKM in Testis
Total median expression: 255.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.60293-0.432 Picture PostScript Text
3' UTR -172.50671-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011990 - TPR-like_helical

ModBase Predicted Comparative 3D Structure on Q3B7T1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC026172 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone MGC:27035 IMAGE:4838438), complete cds.
BC028715 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone IMAGE:4838997), with apparent retained intron.
JD406577 - Sequence 387601 from Patent EP1572962.
BC105929 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone IMAGE:40028898), complete cds.
BC107479 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone MGC:125704 IMAGE:40028896), complete cds.
LF207940 - JP 2014500723-A/15443: Polycomb-Associated Non-Coding RNAs.
BX648348 - Homo sapiens mRNA; cDNA DKFZp686K23170 (from clone DKFZp686K23170).
AK091507 - Homo sapiens cDNA FLJ34188 fis, clone FCBBF3017396, moderately similar to Erythroid differentiation-related factor 1.
AX747027 - Sequence 552 from Patent EP1308459.
JD211067 - Sequence 192091 from Patent EP1572962.
JD141053 - Sequence 122077 from Patent EP1572962.
LF370225 - JP 2014500723-A/177728: Polycomb-Associated Non-Coding RNAs.
LF370228 - JP 2014500723-A/177731: Polycomb-Associated Non-Coding RNAs.
AF040247 - Homo sapiens erythroid differentiation-related factor 1 mRNA, partial cds.
BC107896 - Homo sapiens cDNA clone IMAGE:30321402, containing frame-shift errors.
BC016903 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone IMAGE:3915013).
AK025270 - Homo sapiens cDNA: FLJ21617 fis, clone COL07481.
JD163359 - Sequence 144383 from Patent EP1572962.
AK314958 - Homo sapiens cDNA, FLJ95873.
AL050102 - Homo sapiens mRNA; cDNA DKFZp586F1019 (from clone DKFZp586F1019).
BC029650 - Homo sapiens chromosome 10 open reading frame 137, mRNA (cDNA clone IMAGE:4776366), partial cds.
JD356820 - Sequence 337844 from Patent EP1572962.
JD499764 - Sequence 480788 from Patent EP1572962.
JD233470 - Sequence 214494 from Patent EP1572962.
JD238798 - Sequence 219822 from Patent EP1572962.
MA605802 - JP 2018138019-A/177728: Polycomb-Associated Non-Coding RNAs.
MA605805 - JP 2018138019-A/177731: Polycomb-Associated Non-Coding RNAs.
MA443517 - JP 2018138019-A/15443: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RC65, C10orf137, EDRF1_HUMAN, NM_001202438, NP_001189367, Q3B7T1, Q3KR40, Q4G190, Q5VZQ4, Q8IZ74, Q9Y3W4
UCSC ID: uc001liq.1
RefSeq Accession: NM_001202438
Protein: Q3B7T1 (aka EDRF1_HUMAN)
CCDS: CCDS7646.1, CCDS55733.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001202438.1
exon count: 25CDS single in 3' UTR: no RNA size: 4698
ORF size: 3717CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7340.00frame shift in genome: no % Coverage: 99.64
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 619# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.