Human Gene KANSL3 (uc002swn.5)
  Description: Homo sapiens KAT8 regulatory NSL complex subunit 3 (KANSL3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:97,258,892-97,304,116 Size: 45,225 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr2:97,261,348-97,302,872 Size: 41,525 Coding Exon Count: 20 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:97,258,892-97,304,116)mRNA (may differ from genome)Protein (878 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KANSL3
Diseases sorted by gene-association score: red color blindness (2), calcific tendinitis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.02 RPKM in Testis
Total median expression: 766.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.10147-0.422 Picture PostScript Text
3' UTR -840.152456-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q9P2N6-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Descriptions from all associated GenBank mRNAs
  AK000943 - Homo sapiens cDNA FLJ10081 fis, clone HEMBA1002018.
AK074379 - Homo sapiens cDNA FLJ23799 fis, clone HEP22306.
BC051763 - Homo sapiens KIAA1310, mRNA (cDNA clone IMAGE:6192233), partial cds.
BC024276 - Homo sapiens cDNA clone IMAGE:4111414.
AF311326 - Homo sapiens testis development protein PRTD mRNA, complete cds.
BC063792 - Homo sapiens KIAA1310, mRNA (cDNA clone MGC:70551 IMAGE:6504387), complete cds.
AB037731 - Homo sapiens mRNA for KIAA1310 protein, partial cds.
AK023813 - Homo sapiens cDNA FLJ13751 fis, clone PLACE3000339, weakly similar to GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3).
AY050169 - Homo sapiens serum inhibited-related protein (SI1) mRNA, complete cds.
JD051654 - Sequence 32678 from Patent EP1572962.
JD564705 - Sequence 545729 from Patent EP1572962.
JD521825 - Sequence 502849 from Patent EP1572962.
JD227415 - Sequence 208439 from Patent EP1572962.
JD042565 - Sequence 23589 from Patent EP1572962.
JD265536 - Sequence 246560 from Patent EP1572962.
JD288446 - Sequence 269470 from Patent EP1572962.
JD474650 - Sequence 455674 from Patent EP1572962.
JD363243 - Sequence 344267 from Patent EP1572962.
JD287081 - Sequence 268105 from Patent EP1572962.
JD516586 - Sequence 497610 from Patent EP1572962.
JD362785 - Sequence 343809 from Patent EP1572962.
JD357018 - Sequence 338042 from Patent EP1572962.
JD429218 - Sequence 410242 from Patent EP1572962.
JD400496 - Sequence 381520 from Patent EP1572962.
JD131017 - Sequence 112041 from Patent EP1572962.
JD497156 - Sequence 478180 from Patent EP1572962.
JD054764 - Sequence 35788 from Patent EP1572962.
JD380176 - Sequence 361200 from Patent EP1572962.
JD279248 - Sequence 260272 from Patent EP1572962.
JD488235 - Sequence 469259 from Patent EP1572962.
JD282304 - Sequence 263328 from Patent EP1572962.
JD067074 - Sequence 48098 from Patent EP1572962.
JD263175 - Sequence 244199 from Patent EP1572962.
JD345955 - Sequence 326979 from Patent EP1572962.
JD434355 - Sequence 415379 from Patent EP1572962.
JD148952 - Sequence 129976 from Patent EP1572962.
JD438551 - Sequence 419575 from Patent EP1572962.
JD045296 - Sequence 26320 from Patent EP1572962.
AK302646 - Homo sapiens cDNA FLJ53250 complete cds.
JD223127 - Sequence 204151 from Patent EP1572962.
JD420935 - Sequence 401959 from Patent EP1572962.
AK304011 - Homo sapiens cDNA FLJ55383 complete cds.
JD149146 - Sequence 130170 from Patent EP1572962.
AK314367 - Homo sapiens cDNA, FLJ95135.
KJ894235 - Synthetic construct Homo sapiens clone ccsbBroadEn_03629 KANSL3 gene, encodes complete protein.
AM393078 - Synthetic construct Homo sapiens clone IMAGE:100002424 for hypothetical protein (FLJ10081 gene).
AM393711 - Synthetic construct Homo sapiens clone IMAGE:100002423 for hypothetical protein (FLJ10081 gene).
AL136849 - Homo sapiens mRNA; cDNA DKFZp434B2131 (from clone DKFZp434B2131).
DQ591351 - Homo sapiens piRNA piR-58463, complete sequence.
AB384592 - Synthetic construct DNA, clone: pF1KA1310, Homo sapiens KIAA1310 gene for KIAA1310 protein, complete cds, without stop codon, in Flexi system.
BC127820 - Homo sapiens KIAA1310, mRNA (cDNA clone IMAGE:40131569), partial cds.
AK091163 - Homo sapiens cDNA FLJ33844 fis, clone CTONG2005145, moderately similar to Testis development protein PRTD.
AX746820 - Sequence 345 from Patent EP1308459.
AK311617 - Homo sapiens cDNA, FLJ18659.
BC032746 - Homo sapiens KIAA1310, mRNA (cDNA clone IMAGE:5574236), complete cds.
BC015469 - Homo sapiens KIAA1310, mRNA (cDNA clone IMAGE:3914152), partial cds.
CU687816 - Synthetic construct Homo sapiens gateway clone IMAGE:100022869 5' read FLJ10081 mRNA.
JD230423 - Sequence 211447 from Patent EP1572962.
JD300352 - Sequence 281376 from Patent EP1572962.
JD205096 - Sequence 186120 from Patent EP1572962.
JD121860 - Sequence 102884 from Patent EP1572962.
JD167121 - Sequence 148145 from Patent EP1572962.
JD260241 - Sequence 241265 from Patent EP1572962.
JD059037 - Sequence 40061 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P2N6 (Reactome details) participates in the following event(s):

R-HSA-3321805 NSL acetylates histone H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1310, NM_001115016, NP_001108488, NSL3, PRTD, Q9P2N6-3, SI1, uc002swn.4
UCSC ID: uc002swn.5
RefSeq Accession: NM_001115016
Protein: Q9P2N6-3, splice isoform of Q9P2N6 CCDS: CCDS46361.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001115016.2
exon count: 21CDS single in 3' UTR: no RNA size: 5240
ORF size: 2637CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5453.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.