Human Gene HCFC1 (uc004fjp.3) Description and Page Index
  Description: Homo sapiens host cell factor C1 (VP16-accessory protein) (HCFC1), mRNA.
RefSeq Summary (NM_005334): This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L20010.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000310441.12/ ENSP00000309555.7 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chrX:153,213,008-153,236,819 Size: 23,812 Total Exon Count: 26 Strand: -
Coding Region
   Position: hg19 chrX:153,214,798-153,236,291 Size: 21,494 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:153,213,008-153,236,819)mRNA (may differ from genome)Protein (2035 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Host cell factor 1; Short=HCF; Short=HCF-1; AltName: Full=C1 factor; AltName: Full=CFF; AltName: Full=VCAF; AltName: Full=VP16 accessory protein; Contains: RecName: Full=HCF N-terminal chain 1; Contains: RecName: Full=HCF N-terminal chain 2; Contains: RecName: Full=HCF N-terminal chain 3; Contains: RecName: Full=HCF N-terminal chain 4; Contains: RecName: Full=HCF N-terminal chain 5; Contains: RecName: Full=HCF N-terminal chain 6; Contains: RecName: Full=HCF C-terminal chain 1; Contains: RecName: Full=HCF C-terminal chain 2; Contains: RecName: Full=HCF C-terminal chain 3; Contains: RecName: Full=HCF C-terminal chain 4; Contains: RecName: Full=HCF C-terminal chain 5; Contains: RecName: Full=HCF C-terminal chain 6;
FUNCTION: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
SUBUNIT: Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide. The majority of N- and C-terminal cleavage products remain tightly, albeit non- covalently, associated. Interacts with POU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SDS3), SAP30, SIN3B and FHL2. Component of a MLL1 complex, composed of at least the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, DPY30, E2F6, HCFC2, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8, PELP1, PHF20,. PRP31, RING2, RUVBL1, RUVBL2, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the MLL5-L complex, composed of at least MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Interacts directly with OGT; the interaction, which requires the HCFC1 cleavage site domain, glycosylates and promotes the proteolytic processing of HCFC1, retains OGT in the nucleus and impacts the expression of herpes simplex virus immediate early viral genes. Interacts directly with THAP3 (via its HBM). Interacts (via the Kelch-repeat domain) with THAP1 (via the HBM); the interaction recruits HCHC1 to the RRM1. Interacts with HCFC1R1 and THAP11. Associates with the VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L, CXXC1, HCFC1 and DPY30. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with the viral transactivator protein VP16.
INTERACTION: Self; NbExp=2; IntAct=EBI-396176, EBI-396176; Q9UBL3:ASH2L; NbExp=4; IntAct=EBI-396176, EBI-540797; O43889:CREB3; NbExp=5; IntAct=EBI-396176, EBI-625002; O43889-2:CREB3; NbExp=4; IntAct=EBI-396176, EBI-625022; Q9NS37:CREBZF; NbExp=8; IntAct=EBI-396176, EBI-632965; O43524:FOXO3; NbExp=2; IntAct=EBI-396176, EBI-1644164; Q06546:GABPA; NbExp=2; IntAct=EBI-396176, EBI-638925; Q06547:GABPB1; NbExp=3; IntAct=EBI-396176, EBI-618165; Q06547-2:GABPB1; NbExp=6; IntAct=EBI-396176, EBI-618189; Q13547:HDAC1; NbExp=2; IntAct=EBI-396176, EBI-301834; Q92769:HDAC2; NbExp=2; IntAct=EBI-396176, EBI-301821; O15294:OGT; NbExp=9; IntAct=EBI-396176, EBI-539828; O15047:SETD1A; NbExp=2; IntAct=EBI-396176, EBI-540779; Q96ST3:SIN3A; NbExp=6; IntAct=EBI-396176, EBI-347218; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-396176, EBI-1802965; P08047:SP1; NbExp=4; IntAct=EBI-396176, EBI-298336; Q9H7L9:SUDS3; NbExp=2; IntAct=EBI-396176, EBI-540496; Q96EK4:THAP11; NbExp=2; IntAct=EBI-396176, EBI-1790529; P61964:WDR5; NbExp=4; IntAct=EBI-396176, EBI-540834; Q13105:ZBTB17; NbExp=9; IntAct=EBI-396176, EBI-372156;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER.
TISSUE SPECIFICITY: Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested.
DOMAIN: The HCF repeat is a highly specific proteolytic cleavage signal.
DOMAIN: The kelch repeats fold into a 6-bladed kelch beta- propeller called the beta-propeller domain which mediates interaction with HCFC1R1.
PTM: Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Further cleavage of the primary N- and C- terminal chains results in a 'trimming' and accumulation of the smaller chains. Cleavage is promoted by O-glycosylation.
PTM: O-glycosylated. O-glycosylation promotes proteolytic processing.
PTM: Ubiquitinated. Lys-1807 and Lys-1808 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem to stabilize the protein.
SIMILARITY: Contains 5 Kelch repeats.
SEQUENCE CAUTION: Sequence=CAA55790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HCFC1
CDC HuGE Published Literature: HCFC1

-  MalaCards Disease Associations
  MalaCards Gene Search: HCFC1
Diseases sorted by gene-association score: mental retardation, x-linked 3* (1690), intellectual disability* (96), alacrima, achalasia, and mental retardation syndrome* (72), x-linked non-specific intellectual disability* (71), herpes simplex (43), lymphangitis (16), glanders (11), campylobacteriosis (6), orofaciodigital syndrome viii (5), dengue disease (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.40 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 502.68 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -246.31528-0.466 Picture PostScript Text
3' UTR -698.401790-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF01344 - Kelch motif
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13854 - Kelch motif

SCOP Domains:
49265 - Fibronectin type III
50965 - Galactose oxidase, central domain

ModBase Predicted Comparative 3D Structure on P51610
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0033613 activating transcription factor binding
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007005 mitochondrion organization
GO:0007049 cell cycle
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019046 release from viral latency
GO:0043254 regulation of protein complex assembly
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050821 protein stabilization
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032991 macromolecular complex
GO:0043025 neuronal cell body
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0070461 SAGA-type complex

-  Descriptions from all associated GenBank mRNAs
  LF211529 - JP 2014500723-A/19032: Polycomb-Associated Non-Coding RNAs.
L20010 - Human HCF1 gene related mRNA sequence.
GU014839 - Synthetic construct Homo sapiens clone IMAGE:100068743; MGC:198457 host cell factor 1 (HCFC1) gene, encodes complete protein.
MA447106 - JP 2018138019-A/19032: Polycomb-Associated Non-Coding RNAs.
BC010606 - Homo sapiens host cell factor C1 (VP16-accessory protein), mRNA (cDNA clone IMAGE:4156258), with apparent retained intron.
JD396966 - Sequence 377990 from Patent EP1572962.
JD456716 - Sequence 437740 from Patent EP1572962.
JD283742 - Sequence 264766 from Patent EP1572962.
JD329676 - Sequence 310700 from Patent EP1572962.
JD441640 - Sequence 422664 from Patent EP1572962.
JD383591 - Sequence 364615 from Patent EP1572962.
JD188984 - Sequence 170008 from Patent EP1572962.
JD547556 - Sequence 528580 from Patent EP1572962.
LF211530 - JP 2014500723-A/19033: Polycomb-Associated Non-Coding RNAs.
JD481531 - Sequence 462555 from Patent EP1572962.
JD482856 - Sequence 463880 from Patent EP1572962.
JD114647 - Sequence 95671 from Patent EP1572962.
JD211627 - Sequence 192651 from Patent EP1572962.
JD250048 - Sequence 231072 from Patent EP1572962.
JD040225 - Sequence 21249 from Patent EP1572962.
JD318718 - Sequence 299742 from Patent EP1572962.
JD544086 - Sequence 525110 from Patent EP1572962.
JD445551 - Sequence 426575 from Patent EP1572962.
JD431257 - Sequence 412281 from Patent EP1572962.
JD509659 - Sequence 490683 from Patent EP1572962.
JD419382 - Sequence 400406 from Patent EP1572962.
JD383371 - Sequence 364395 from Patent EP1572962.
JD380411 - Sequence 361435 from Patent EP1572962.
JD424368 - Sequence 405392 from Patent EP1572962.
JD426199 - Sequence 407223 from Patent EP1572962.
JD302273 - Sequence 283297 from Patent EP1572962.
JD540728 - Sequence 521752 from Patent EP1572962.
JD298614 - Sequence 279638 from Patent EP1572962.
JD275221 - Sequence 256245 from Patent EP1572962.
LF380779 - JP 2014500723-A/188282: Polycomb-Associated Non-Coding RNAs.
JD519653 - Sequence 500677 from Patent EP1572962.
JD106373 - Sequence 87397 from Patent EP1572962.
JD162299 - Sequence 143323 from Patent EP1572962.
JD361785 - Sequence 342809 from Patent EP1572962.
JD335818 - Sequence 316842 from Patent EP1572962.
JD335817 - Sequence 316841 from Patent EP1572962.
JD077209 - Sequence 58233 from Patent EP1572962.
JD415394 - Sequence 396418 from Patent EP1572962.
JD460467 - Sequence 441491 from Patent EP1572962.
JD285258 - Sequence 266282 from Patent EP1572962.
LF380780 - JP 2014500723-A/188283: Polycomb-Associated Non-Coding RNAs.
JD556597 - Sequence 537621 from Patent EP1572962.
JD551286 - Sequence 532310 from Patent EP1572962.
JD214029 - Sequence 195053 from Patent EP1572962.
JD445695 - Sequence 426719 from Patent EP1572962.
JD045216 - Sequence 26240 from Patent EP1572962.
LF380781 - JP 2014500723-A/188284: Polycomb-Associated Non-Coding RNAs.
JD178245 - Sequence 159269 from Patent EP1572962.
JD234690 - Sequence 215714 from Patent EP1572962.
JD467589 - Sequence 448613 from Patent EP1572962.
JD559567 - Sequence 540591 from Patent EP1572962.
JD410257 - Sequence 391281 from Patent EP1572962.
JD247360 - Sequence 228384 from Patent EP1572962.
JD126979 - Sequence 108003 from Patent EP1572962.
LF380782 - JP 2014500723-A/188285: Polycomb-Associated Non-Coding RNAs.
LF380784 - JP 2014500723-A/188287: Polycomb-Associated Non-Coding RNAs.
LF380785 - JP 2014500723-A/188288: Polycomb-Associated Non-Coding RNAs.
LF380786 - JP 2014500723-A/188289: Polycomb-Associated Non-Coding RNAs.
LF380787 - JP 2014500723-A/188290: Polycomb-Associated Non-Coding RNAs.
LF380788 - JP 2014500723-A/188291: Polycomb-Associated Non-Coding RNAs.
LF380789 - JP 2014500723-A/188292: Polycomb-Associated Non-Coding RNAs.
LF380790 - JP 2014500723-A/188293: Polycomb-Associated Non-Coding RNAs.
LF380791 - JP 2014500723-A/188294: Polycomb-Associated Non-Coding RNAs.
LF380792 - JP 2014500723-A/188295: Polycomb-Associated Non-Coding RNAs.
LF380793 - JP 2014500723-A/188296: Polycomb-Associated Non-Coding RNAs.
MA447107 - JP 2018138019-A/19033: Polycomb-Associated Non-Coding RNAs.
MA616356 - JP 2018138019-A/188282: Polycomb-Associated Non-Coding RNAs.
MA616357 - JP 2018138019-A/188283: Polycomb-Associated Non-Coding RNAs.
MA616358 - JP 2018138019-A/188284: Polycomb-Associated Non-Coding RNAs.
MA616359 - JP 2018138019-A/188285: Polycomb-Associated Non-Coding RNAs.
MA616361 - JP 2018138019-A/188287: Polycomb-Associated Non-Coding RNAs.
MA616362 - JP 2018138019-A/188288: Polycomb-Associated Non-Coding RNAs.
MA616363 - JP 2018138019-A/188289: Polycomb-Associated Non-Coding RNAs.
MA616364 - JP 2018138019-A/188290: Polycomb-Associated Non-Coding RNAs.
MA616365 - JP 2018138019-A/188291: Polycomb-Associated Non-Coding RNAs.
MA616366 - JP 2018138019-A/188292: Polycomb-Associated Non-Coding RNAs.
MA616367 - JP 2018138019-A/188293: Polycomb-Associated Non-Coding RNAs.
MA616368 - JP 2018138019-A/188294: Polycomb-Associated Non-Coding RNAs.
MA616369 - JP 2018138019-A/188295: Polycomb-Associated Non-Coding RNAs.
MA616370 - JP 2018138019-A/188296: Polycomb-Associated Non-Coding RNAs.
LF380794 - JP 2014500723-A/188297: Polycomb-Associated Non-Coding RNAs.
LF380795 - JP 2014500723-A/188298: Polycomb-Associated Non-Coding RNAs.
LF380796 - JP 2014500723-A/188299: Polycomb-Associated Non-Coding RNAs.
LF380797 - JP 2014500723-A/188300: Polycomb-Associated Non-Coding RNAs.
BC019887 - Homo sapiens host cell factor C1 (VP16-accessory protein), mRNA (cDNA clone IMAGE:5142023), partial cds.
BC030560 - Homo sapiens host cell factor C1 (VP16-accessory protein), mRNA (cDNA clone IMAGE:5242489), partial cds.
KJ901476 - Synthetic construct Homo sapiens clone ccsbBroadEn_10870 HCFC1 gene, encodes complete protein.
BC063435 - Homo sapiens host cell factor C1 (VP16-accessory protein), mRNA (cDNA clone IMAGE:5395387), complete cds.
LF380798 - JP 2014500723-A/188301: Polycomb-Associated Non-Coding RNAs.
CU687716 - Synthetic construct Homo sapiens gateway clone IMAGE:100021760 5' read HCFC1 mRNA.
DQ655939 - Homo sapiens clone UGL5g06, mRNA sequence.
LF380802 - JP 2014500723-A/188305: Polycomb-Associated Non-Coding RNAs.
JD174249 - Sequence 155273 from Patent EP1572962.
JD265030 - Sequence 246054 from Patent EP1572962.
JD554792 - Sequence 535816 from Patent EP1572962.
LF380814 - JP 2014500723-A/188317: Polycomb-Associated Non-Coding RNAs.
LF211531 - JP 2014500723-A/19034: Polycomb-Associated Non-Coding RNAs.
LF380815 - JP 2014500723-A/188318: Polycomb-Associated Non-Coding RNAs.
LF380816 - JP 2014500723-A/188319: Polycomb-Associated Non-Coding RNAs.
JD462735 - Sequence 443759 from Patent EP1572962.
MA616371 - JP 2018138019-A/188297: Polycomb-Associated Non-Coding RNAs.
MA616372 - JP 2018138019-A/188298: Polycomb-Associated Non-Coding RNAs.
MA616373 - JP 2018138019-A/188299: Polycomb-Associated Non-Coding RNAs.
MA616374 - JP 2018138019-A/188300: Polycomb-Associated Non-Coding RNAs.
MA616375 - JP 2018138019-A/188301: Polycomb-Associated Non-Coding RNAs.
MA616379 - JP 2018138019-A/188305: Polycomb-Associated Non-Coding RNAs.
MA616391 - JP 2018138019-A/188317: Polycomb-Associated Non-Coding RNAs.
MA447108 - JP 2018138019-A/19034: Polycomb-Associated Non-Coding RNAs.
MA616392 - JP 2018138019-A/188318: Polycomb-Associated Non-Coding RNAs.
MA616393 - JP 2018138019-A/188319: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P51610 (Reactome details) participates in the following event(s):

R-HSA-1592250 NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter
R-HSA-2466367 NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter
R-HSA-5690785 BAP1 binds Ub-HCFC1
R-HSA-5690759 BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
R-HSA-3321805 NSL acetylates histone H4
R-HSA-5689630 BAP1 binds BAP1-interacting complex
R-HSA-5690790 Histone H2A is dubiquitinated by the PR-DUB complex
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-5689603 UCH proteinases
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-5688426 Deubiquitination
R-HSA-3214847 HATs acetylate histones
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-597592 Post-translational protein modification
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-392499 Metabolism of proteins
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: HCF1, HCFC1_HUMAN, HFC1, NM_005334, NP_005325, P51610, Q6P4G5
UCSC ID: uc004fjp.3
RefSeq Accession: NM_005334
Protein: P51610 (aka HCFC1_HUMAN or HFC1_HUMAN)
CCDS: CCDS44020.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HCFC1:
cbl (Disorders of Intracellular Cobalamin Metabolism)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_005334.2
exon count: 26CDS single in 3' UTR: no RNA size: 8436
ORF size: 6108CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 11286.00frame shift in genome: no % Coverage: 99.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.