Human Gene CHMP7 (uc003xdc.2) Description and Page Index
  Description: Homo sapiens charged multivesicular body protein 7 (CHMP7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:23,101,150-23,119,512 Size: 18,363 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr8:23,104,209-23,118,112 Size: 13,904 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:23,101,150-23,119,512)mRNA (may differ from genome)Protein (453 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: CHMP7_HUMAN
DESCRIPTION: RecName: Full=Charged multivesicular body protein 7; AltName: Full=Chromatin-modifying protein 7;
FUNCTION: Plays a role in the endosomal sorting pathway.
SUBUNIT: Interacts with CHMP4B, but not with VPS25.
SUBCELLULAR LOCATION: Cytoplasm. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area.
SIMILARITY: Belongs to the SNF7 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CHMP7
CDC HuGE Published Literature: CHMP7

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.41 RPKM in Spleen
Total median expression: 572.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -244.80648-0.378 Picture PostScript Text
3' UTR -505.521400-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005024 - Snf7

Pfam Domains:
PF03357 - Snf7
PF16662 - FLYWCH-type zinc finger-containing protein 1

ModBase Predicted Comparative 3D Structure on Q8WUX9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008565 protein transporter activity

Biological Process:
GO:0000920 cell separation after cytokinesis
GO:0006997 nucleus organization
GO:0007034 vacuolar transport
GO:0007080 mitotic metaphase plate congression
GO:0010458 exit from mitosis
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0031468 nuclear envelope reassembly
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0045324 late endosome to vacuole transport
GO:0071168 protein localization to chromatin
GO:1904903 ESCRT III complex disassembly

Cellular Component:
GO:0000815 ESCRT III complex
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0000785 chromatin


-  Descriptions from all associated GenBank mRNAs
  AK097202 - Homo sapiens cDNA FLJ39883 fis, clone SPLEN2016268, highly similar to Protein CHMP7.
BC042050 - Homo sapiens CHMP family, member 7, mRNA (cDNA clone MGC:50403 IMAGE:5551762), complete cds.
AK315664 - Homo sapiens cDNA, FLJ96756.
AK021776 - Homo sapiens cDNA FLJ11714 fis, clone HEMBA1005219, highly similar to Protein CHMP7.
AK092500 - Homo sapiens cDNA FLJ35181 fis, clone PLACE6015051, highly similar to Protein CHMP7.
AX747573 - Sequence 1098 from Patent EP1308459.
AL833843 - Homo sapiens mRNA; cDNA DKFZp434C191 (from clone DKFZp434C191).
BC019110 - Homo sapiens CHMP family, member 7, mRNA (cDNA clone MGC:29816 IMAGE:5093453), complete cds.
AK296592 - Homo sapiens cDNA FLJ57739 complete cds, highly similar to Protein CHMP7.
CU676386 - Synthetic construct Homo sapiens gateway clone IMAGE:100017666 5' read CHMP7 mRNA.
KJ895168 - Synthetic construct Homo sapiens clone ccsbBroadEn_04562 CHMP7 gene, encodes complete protein.
BC004344 - Homo sapiens CHMP family, member 7, mRNA (cDNA clone IMAGE:3633354), partial cds.
AL832313 - Homo sapiens mRNA; cDNA DKFZp667O2019 (from clone DKFZp667O2019).
JD539182 - Sequence 520206 from Patent EP1572962.
JD330904 - Sequence 311928 from Patent EP1572962.
JD539289 - Sequence 520313 from Patent EP1572962.
JD178041 - Sequence 159065 from Patent EP1572962.
JD431809 - Sequence 412833 from Patent EP1572962.
JD226112 - Sequence 207136 from Patent EP1572962.
JD115569 - Sequence 96593 from Patent EP1572962.
JD368080 - Sequence 349104 from Patent EP1572962.
JD434768 - Sequence 415792 from Patent EP1572962.
JD476368 - Sequence 457392 from Patent EP1572962.
JD555222 - Sequence 536246 from Patent EP1572962.
JD520236 - Sequence 501260 from Patent EP1572962.
JD138978 - Sequence 120002 from Patent EP1572962.
JD457704 - Sequence 438728 from Patent EP1572962.
JD074330 - Sequence 55354 from Patent EP1572962.
JD312559 - Sequence 293583 from Patent EP1572962.
JD381410 - Sequence 362434 from Patent EP1572962.
JD399744 - Sequence 380768 from Patent EP1572962.
JD422674 - Sequence 403698 from Patent EP1572962.
JD060761 - Sequence 41785 from Patent EP1572962.
JD367141 - Sequence 348165 from Patent EP1572962.
JD270412 - Sequence 251436 from Patent EP1572962.
JD208034 - Sequence 189058 from Patent EP1572962.
JD069143 - Sequence 50167 from Patent EP1572962.
JD339474 - Sequence 320498 from Patent EP1572962.
JD048520 - Sequence 29544 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WUX9 (Reactome details) participates in the following event(s):

R-HSA-917693 ESCRT Disassembly
R-HSA-917700 MVB Vesicle Formation
R-HSA-3159232 Recruitment Of HIV Virion Budding Machinery
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-162588 Budding and maturation of HIV virion
R-HSA-199991 Membrane Trafficking
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-5653656 Vesicle-mediated transport
R-HSA-162587 HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDT3, CHMP7_HUMAN, D3DSS1, NM_152272, NP_689485, Q8NDM1, Q8WUX9, Q9BT50
UCSC ID: uc003xdc.2
RefSeq Accession: NM_152272
Protein: Q8WUX9 (aka CHMP7_HUMAN)
CCDS: CCDS6040.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152272.3
exon count: 11CDS single in 3' UTR: no RNA size: 3420
ORF size: 1362CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2279.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.