Human Gene TMEM131 (uc002syh.4) Description and Page Index
  Description: Homo sapiens transmembrane protein 131 (TMEM131), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:98,372,801-98,612,354 Size: 239,554 Total Exon Count: 41 Strand: -
Coding Region
   Position: hg19 chr2:98,373,562-98,612,125 Size: 238,564 Coding Exon Count: 41 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:98,372,801-98,612,354)mRNA (may differ from genome)Protein (1883 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: TM131_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 131; AltName: Full=Protein RW1;
FUNCTION: May play a role in the immune response to viral infection (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM131 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM131
CDC HuGE Published Literature: TMEM131
Positive Disease Associations: Exercise Test , Heart Rate
Related Studies:
  1. Exercise Test
    Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics. [PubMed 17903301]
    In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
  2. Heart Rate
    Christopher Newton-Cheh et al. BMC medical genetics 2007, Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study., BMC medical genetics. [PubMed 17903306]
    In the community-based Framingham Heart Study none of the ECG and HRV results individually attained genomewide significance. However, the presence of bona fide QT-associated SNPs among the top 117 results for QT duration supports the importance of efforts to validate top results from the reported scans. Finding genetic variants associated with ECG and HRV quantitative traits may identify novel genes and pathways implicated in arrhythmogenesis and allow for improved recognition of individuals at high risk for arrhythmias in the general population.

-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM131
Diseases sorted by gene-association score: subdural empyema (2), streptococcal meningitis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.49 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 521.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.40229-0.456 Picture PostScript Text
3' UTR -181.40761-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022113 - DUF3651_TMEM131
IPR008962 - PapD-like

Pfam Domains:
PF12371 - Transmembrane protein 131-like

ModBase Predicted Comparative 3D Structure on Q92545
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF383599 - JP 2014500723-A/191102: Polycomb-Associated Non-Coding RNAs.
AK098792 - Homo sapiens cDNA FLJ25926 fis, clone CBR05159, highly similar to Mus musculus RW1 protein mRNA.
AK297450 - Homo sapiens cDNA FLJ55106 complete cds, highly similar to Transmembrane protein 131.
MA619176 - JP 2018138019-A/191102: Polycomb-Associated Non-Coding RNAs.
D87446 - Homo sapiens mRNA for KIAA0257 gene, partial cds.
BC018018 - Homo sapiens transmembrane protein 131, mRNA (cDNA clone IMAGE:4285841).
BC036841 - Homo sapiens transmembrane protein 131, mRNA (cDNA clone IMAGE:5213717), complete cds.
BX647728 - Homo sapiens mRNA; cDNA DKFZp686G2424 (from clone DKFZp686G2424).
AK025852 - Homo sapiens cDNA: FLJ22199 fis, clone HRC01245.
LF317369 - JP 2014500723-A/124872: Polycomb-Associated Non-Coding RNAs.
LF317370 - JP 2014500723-A/124873: Polycomb-Associated Non-Coding RNAs.
JD338023 - Sequence 319047 from Patent EP1572962.
LF317371 - JP 2014500723-A/124874: Polycomb-Associated Non-Coding RNAs.
KJ902348 - Synthetic construct Homo sapiens clone ccsbBroadEn_11742 TMEM131 gene, encodes complete protein.
LF317372 - JP 2014500723-A/124875: Polycomb-Associated Non-Coding RNAs.
LF317374 - JP 2014500723-A/124877: Polycomb-Associated Non-Coding RNAs.
LF317376 - JP 2014500723-A/124879: Polycomb-Associated Non-Coding RNAs.
LF317377 - JP 2014500723-A/124880: Polycomb-Associated Non-Coding RNAs.
LF317378 - JP 2014500723-A/124881: Polycomb-Associated Non-Coding RNAs.
LF317379 - JP 2014500723-A/124882: Polycomb-Associated Non-Coding RNAs.
LF317380 - JP 2014500723-A/124883: Polycomb-Associated Non-Coding RNAs.
LF317381 - JP 2014500723-A/124884: Polycomb-Associated Non-Coding RNAs.
LF317382 - JP 2014500723-A/124885: Polycomb-Associated Non-Coding RNAs.
LF317383 - JP 2014500723-A/124886: Polycomb-Associated Non-Coding RNAs.
LF317385 - JP 2014500723-A/124888: Polycomb-Associated Non-Coding RNAs.
LF317386 - JP 2014500723-A/124889: Polycomb-Associated Non-Coding RNAs.
LF317387 - JP 2014500723-A/124890: Polycomb-Associated Non-Coding RNAs.
LF317388 - JP 2014500723-A/124891: Polycomb-Associated Non-Coding RNAs.
LF317389 - JP 2014500723-A/124892: Polycomb-Associated Non-Coding RNAs.
LF317391 - JP 2014500723-A/124894: Polycomb-Associated Non-Coding RNAs.
LF317392 - JP 2014500723-A/124895: Polycomb-Associated Non-Coding RNAs.
LF317393 - JP 2014500723-A/124896: Polycomb-Associated Non-Coding RNAs.
LF317394 - JP 2014500723-A/124897: Polycomb-Associated Non-Coding RNAs.
MA552946 - JP 2018138019-A/124872: Polycomb-Associated Non-Coding RNAs.
MA552947 - JP 2018138019-A/124873: Polycomb-Associated Non-Coding RNAs.
MA552948 - JP 2018138019-A/124874: Polycomb-Associated Non-Coding RNAs.
MA552949 - JP 2018138019-A/124875: Polycomb-Associated Non-Coding RNAs.
MA552951 - JP 2018138019-A/124877: Polycomb-Associated Non-Coding RNAs.
MA552953 - JP 2018138019-A/124879: Polycomb-Associated Non-Coding RNAs.
MA552954 - JP 2018138019-A/124880: Polycomb-Associated Non-Coding RNAs.
MA552955 - JP 2018138019-A/124881: Polycomb-Associated Non-Coding RNAs.
MA552956 - JP 2018138019-A/124882: Polycomb-Associated Non-Coding RNAs.
MA552957 - JP 2018138019-A/124883: Polycomb-Associated Non-Coding RNAs.
MA552958 - JP 2018138019-A/124884: Polycomb-Associated Non-Coding RNAs.
MA552959 - JP 2018138019-A/124885: Polycomb-Associated Non-Coding RNAs.
MA552960 - JP 2018138019-A/124886: Polycomb-Associated Non-Coding RNAs.
MA552962 - JP 2018138019-A/124888: Polycomb-Associated Non-Coding RNAs.
MA552963 - JP 2018138019-A/124889: Polycomb-Associated Non-Coding RNAs.
MA552964 - JP 2018138019-A/124890: Polycomb-Associated Non-Coding RNAs.
MA552965 - JP 2018138019-A/124891: Polycomb-Associated Non-Coding RNAs.
MA552966 - JP 2018138019-A/124892: Polycomb-Associated Non-Coding RNAs.
MA552968 - JP 2018138019-A/124894: Polycomb-Associated Non-Coding RNAs.
MA552969 - JP 2018138019-A/124895: Polycomb-Associated Non-Coding RNAs.
MA552970 - JP 2018138019-A/124896: Polycomb-Associated Non-Coding RNAs.
MA552971 - JP 2018138019-A/124897: Polycomb-Associated Non-Coding RNAs.
LF317396 - JP 2014500723-A/124899: Polycomb-Associated Non-Coding RNAs.
LF317399 - JP 2014500723-A/124902: Polycomb-Associated Non-Coding RNAs.
LF317400 - JP 2014500723-A/124903: Polycomb-Associated Non-Coding RNAs.
LF317403 - JP 2014500723-A/124906: Polycomb-Associated Non-Coding RNAs.
MA552973 - JP 2018138019-A/124899: Polycomb-Associated Non-Coding RNAs.
MA552976 - JP 2018138019-A/124902: Polycomb-Associated Non-Coding RNAs.
MA552977 - JP 2018138019-A/124903: Polycomb-Associated Non-Coding RNAs.
MA552980 - JP 2018138019-A/124906: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0257, NM_015348, NP_056163, Q92545, RW1, TM131_HUMAN
UCSC ID: uc002syh.4
RefSeq Accession: NM_015348
Protein: Q92545 (aka TM131_HUMAN)
CCDS: CCDS46368.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015348.1
exon count: 41CDS single in 3' UTR: no RNA size: 6657
ORF size: 5652CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 8843.00frame shift in genome: no % Coverage: 99.77
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.