Human Gene NUBP2 (uc002cmw.4) Description and Page Index
  Description: Homo sapiens nucleotide binding protein 2 (NUBP2), mRNA.
RefSeq Summary (NM_012225): This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013].
Transcript (Including UTRs)
   Position: hg19 chr16:1,832,933-1,839,192 Size: 6,260 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr16:1,833,022-1,838,715 Size: 5,694 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:1,832,933-1,839,192)mRNA (may differ from genome)Protein (271 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2; AltName: Full=Nucleotide-binding protein 2; Short=NBP 2;
FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer a labile 4Fe-4S cluster to target apoproteins (By similarity).
SUBUNIT: Interacts with KIFC1 (By similarity). Interacts with NUBP1.
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Enriched at the centrosomes during mitosis (By similarity).
TISSUE SPECIFICITY: Widely expressed with highest expression in skeletal muscle.
DEVELOPMENTAL STAGE: Expressed in fetal brain, lung, liver and kidney.
SIMILARITY: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NUBP2
CDC HuGE Published Literature: NUBP2
Positive Disease Associations: Insulin-Like Growth Factor Binding Protein 5
Related Studies:
  1. Insulin-Like Growth Factor Binding Protein 5
    Robert C Kaplan et al. Human molecular genetics 2011, A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3., Human molecular genetics. [PubMed 21216879]

-  MalaCards Disease Associations
  MalaCards Gene Search: NUBP2
Diseases sorted by gene-association score: autonomic nervous system neoplasm (1), peripheral nervous system neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.95 RPKM in Prostate
Total median expression: 577.50 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.7089-0.435 Picture PostScript Text
3' UTR -225.42477-0.473 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025669 - AAA_dom
IPR019591 - ATPase-like_ParA/MinD
IPR000808 - Mrp_CS

Pfam Domains:
PF01656 - CobQ/CobB/MinD/ParA nucleotide binding domain
PF02374 - Anion-transporting ATPase
PF09140 - ATPase MipZ
PF10609 - NUBPL iron-transfer P-loop NTPase
PF13614 - AAA domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9Y5Y2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsemblFlyBase SGD
 Protein SequenceProtein SequenceProtein Sequence Protein Sequence
 AlignmentAlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process:
GO:0016226 iron-sulfur cluster assembly
GO:0030030 cell projection organization

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0031616 spindle pole centrosome
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  AK093593 - Homo sapiens cDNA FLJ36274 fis, clone THYMU2003133, weakly similar to Homo sapiens putative nucleotide binding protein mRNA.
AX748219 - Sequence 1744 from Patent EP1308459.
BC008005 - Homo sapiens nucleotide binding protein 2 (MinD homolog, E. coli), mRNA (cDNA clone MGC:15834 IMAGE:3507768), complete cds.
AK001023 - Homo sapiens cDNA FLJ10161 fis, clone HEMBA1003555, moderately similar to NUCLEOTIDE-BINDING PROTEIN.
AF118394 - Homo sapiens putative nucleotide binding protein mRNA, complete cds.
BC002768 - Homo sapiens nucleotide binding protein 2 (MinD homolog, E. coli), mRNA (cDNA clone MGC:3473 IMAGE:3633393), complete cds.
BX648907 - Homo sapiens mRNA; cDNA DKFZp686N08258 (from clone DKFZp686N08258).
AK315611 - Homo sapiens cDNA, FLJ96692, highly similar to Homo sapiens nucleotide binding protein 2 (MinD homolog, E. coli) (NUBP2), mRNA.
AK300696 - Homo sapiens cDNA FLJ57200 complete cds, highly similar to Nucleotide-binding protein 2.
CU675895 - Synthetic construct Homo sapiens gateway clone IMAGE:100016943 5' read NUBP2 mRNA.
KJ898157 - Synthetic construct Homo sapiens clone ccsbBroadEn_07551 NUBP2 gene, encodes complete protein.
AK124460 - Homo sapiens cDNA FLJ42469 fis, clone BRACE2030345, moderately similar to Homo sapiens nucleotide binding protein 2 (NUBP2).
JD336701 - Sequence 317725 from Patent EP1572962.
JD406589 - Sequence 387613 from Patent EP1572962.
JD158157 - Sequence 139181 from Patent EP1572962.
JD237299 - Sequence 218323 from Patent EP1572962.
JD384166 - Sequence 365190 from Patent EP1572962.
JD189275 - Sequence 170299 from Patent EP1572962.
JD364077 - Sequence 345101 from Patent EP1572962.
JD335244 - Sequence 316268 from Patent EP1572962.
JD187590 - Sequence 168614 from Patent EP1572962.
JD173627 - Sequence 154651 from Patent EP1572962.
JD546937 - Sequence 527961 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y5Y2 (Reactome details) participates in the following event(s):

R-HSA-2564830 Cytosolic iron-sulfur cluster assembly
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: D3DU80, NM_012225, NP_036357, NUBP2_HUMAN, Q9NWB2, Q9Y5Y2
UCSC ID: uc002cmw.4
RefSeq Accession: NM_012225
Protein: Q9Y5Y2 (aka NUBP2_HUMAN or NBP2_HUMAN)
CCDS: CCDS10445.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_012225.2
exon count: 7CDS single in 3' UTR: no RNA size: 1399
ORF size: 816CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1832.00frame shift in genome: no % Coverage: 98.78
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.