ID:FA48A_HUMAN DESCRIPTION: RecName: Full=Protein FAM48A; AltName: Full=p38-interacting protein; Short=p38IP; FUNCTION: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down- regulation of E-cadherin during gastrulation by regulating E- cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation- induced ATG9A trafficking during autophagy. SUBUNIT: Interacts with MAPK14. Interacts with ATG9A. INTERACTION: Q16539:MAPK14; NbExp=5; IntAct=EBI-946984, EBI-73946; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down- regulated in malignant prostate tissues. SIMILARITY: Belongs to the FAM48 family. SEQUENCE CAUTION: Sequence=AAQ15220.1; Type=Frameshift; Positions=562;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NEM7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF093250 - Homo sapiens P38IP (P38IP) mRNA, complete cds. AK225376 - Homo sapiens mRNA for family with sequence similarity 48, member A isoform b variant, clone: HRC01478. AJ130894 - Homo sapiens mRNA for transcription factor. BC001145 - Homo sapiens family with sequence similarity 48, member A, mRNA (cDNA clone MGC:1172 IMAGE:3533877), complete cds. BC030686 - Homo sapiens family with sequence similarity 48, member A, mRNA (cDNA clone MGC:26084 IMAGE:4826077), complete cds. AK292376 - Homo sapiens cDNA FLJ77238 complete cds. KJ899153 - Synthetic construct Homo sapiens clone ccsbBroadEn_08547 FAM48A gene, encodes complete protein. DQ891621 - Synthetic construct clone IMAGE:100004251; FLH178709.01X; RZPDo839G03128D family with sequence similarity 48, member A (FAM48A) gene, encodes complete protein. DQ896826 - Synthetic construct Homo sapiens clone IMAGE:100011286; FLH178706.01L; RZPDo839G03127D family with sequence similarity 48, member A (FAM48A) gene, encodes complete protein. AB590311 - Synthetic construct DNA, clone: pFN21AB6273, Homo sapiens FAM48A gene for family with sequence similarity 48, member A, without stop codon, in Flexi system. AK304227 - Homo sapiens cDNA FLJ54575 complete cds, highly similar to Protein FAM48A. AK027554 - Homo sapiens cDNA FLJ14648 fis, clone NT2RP2002046, highly similar to Protein FAM48A. CU688982 - Synthetic construct Homo sapiens gateway clone IMAGE:100020077 5' read FAM48A mRNA. AF445026 - Homo sapiens clone 111 tumor rejection antigen mRNA, complete cds. AF370384 - Homo sapiens FP757 mRNA, complete cds. AK056121 - Homo sapiens cDNA FLJ31559 fis, clone NT2RI2001385, highly similar to Homo sapiens P38IP mRNA. AK026091 - Homo sapiens cDNA: FLJ22438 fis, clone HRC09232, highly similar to AF093250 Homo sapiens P38IP (P38IP) mRNA. AK093723 - Homo sapiens cDNA FLJ36404 fis, clone THYMU2010030. AK127995 - Homo sapiens cDNA FLJ46113 fis, clone TESTI2036285. JD305128 - Sequence 286152 from Patent EP1572962. JD459275 - Sequence 440299 from Patent EP1572962.